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Use of imidazole alkaloids as anti-Infective medicament synergists and medicinal composition containing anti-Infective medicament synergists

A technology of bisbenzylisoquinoline and synergist is applied in the directions of anti-infective drugs, drug combinations, medical preparations containing active ingredients, etc., and can solve problems such as bisbenzylisoquinoline alkaloids that have not yet been seen , to achieve the effect of reducing adverse reactions, reducing drug resistance, and reducing dosage

Inactive Publication Date: 2010-07-21
张宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no reports of other bisbenzylisoquinoline alkaloids as anti-infective drug synergists

Method used

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  • Use of imidazole alkaloids as anti-Infective medicament synergists and medicinal composition containing anti-Infective medicament synergists
  • Use of imidazole alkaloids as anti-Infective medicament synergists and medicinal composition containing anti-Infective medicament synergists
  • Use of imidazole alkaloids as anti-Infective medicament synergists and medicinal composition containing anti-Infective medicament synergists

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Embodiment Construction

[0038] The inventors of the present invention have carried out long-term research on natural substances or synthetic derivatives containing general formula (I) and their clinical applications with synergistic activity of anti-infective drugs, and found that they all have good reverse anti-inflammatory effects in the laboratory and clinically. The role of drug resistance in infections.

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Abstract

The invention of the invention discloses the use of imidazole alkaloids of a general formula (I) and pharmaceutically acceptable salts thereof in the preparation of anti-Infective medicament synergists and medicinal compositions containing the synergists.

Description

technical field [0001] The present invention relates to an anti-infection drug synergist, in particular, the present invention relates to the use of bisbenzylisoquinoline alkaloids or a pharmaceutically acceptable salt thereof as an anti-infection drug synergist and its pharmaceutical composition. Background technique [0002] Drug resistance is the relative resistance of pathogens to antipathogenic drugs. The emergence of drug resistance in pathogens is a law of nature, that is, its generation is the inevitable result of the long-term evolution of drug resistance genes, and it does not appear after the introduction of anti-infective drugs. Pathogen drug resistance is divided into natural resistance (natural resistance), acquired resistance (acquired resistance), multi-drug resistance (multi-drug resistance, MDR) and cross resistance (cross resistance). Intrinsic drug resistance is also called endogenous drug resistance (intrinsic resistance), which determines the antibacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P31/04A61P31/10A61P31/12A61P33/02C07D491/18
CPCY02A50/30
Inventor 张宏张革化
Owner 张宏
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