Method for desalination and concentration of medical intermediate

An intermediate and desalination technology, applied in the field of desalination and concentration of pharmaceutical intermediates, can solve the problems of cumbersome operation of ion exchange method, high operating cost of resin replacement, and great occupational hazards of operators, achieving a high degree of automation control and increasing the number of enterprises Economic benefits, the effect of small footprint

Inactive Publication Date: 2010-07-14
HANGZHOU TIAN CHUANG ENVIRONMENTAL TECH
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  • Description
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  • Application Information

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Problems solved by technology

The solvent method has the disadvantages of large loss of solvent during use, difficulty in solvent recovery, many technical procedures, and great occupational hazards to operators; ultrafiltration is difficult to achieve percolation for medium and low molecular weight substances. Smaller substances are even more difficult to achieve desalination and concentration; the ion exchange method also has disadvantages such as cumbersome operation, resin replacement and high operating costs.

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  • Method for desalination and concentration of medical intermediate
  • Method for desalination and concentration of medical intermediate
  • Method for desalination and concentration of medical intermediate

Examples

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Embodiment 1

[0014] Embodiment 1: with reference to attached figure 1 with 2 . The desalination and concentration method of pharmaceutical intermediates uses nanofiltration constant volume desalination technology to desalt and concentrate pharmaceutical intermediates. The specific steps: 1) pass the raw materials of pharmaceutical intermediates containing 1% to 25% salt through microfiltration membrane and ultrafiltration The filter membrane removes macromolecular particles, organic matter and colloidal substances in the solution; 2) the raw material solution after removing macromolecular particles, organic matter and colloidal substances enters the water tank and cools down to 10°C to 25°C through cooling water; 3) the cooled The raw material liquid is pressurized by the booster pump and the high-pressure pump in turn, and the nanofiltration constant-capacity desalination technology is used to wash and concentrate the pharmaceutical intermediates, and the rate of adding leachate during t...

Embodiment 2

[0020] Embodiment 2: with reference to attached figure 2. A system for desalting and concentrating pharmaceutical intermediates, the raw material liquid supply pipeline is connected to the inlet of water tank 1, the outlet of water tank 1 is connected to the inlet of primary nanofiltration membrane module 2 through booster pump 7 and high-pressure pump 8, and the primary nanofiltration membrane module 2 is connected to the outlet of water tank 1. The filter membrane module 2 is provided with a concentrated liquid outlet and a permeate outlet, wherein the permeate outlet is connected to the inlet of the water tank 9 through a pipeline, and the outlet of the water tank 9 is connected to the inlet of the secondary nanofiltration membrane module 3 through a booster pump 10 and a high-pressure pump 11 , the concentrate outlet is provided with two outlets, one of which is connected to the inlet of the water tank 1 through a valve and a pipeline, and the other outlet is connected to...

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Abstract

The invention relates to a method for desalination and concentration of a medical intermediate, which not only can simplify the original operational technology, but also can obtain higher purity products, and simultaneously reduces the productive cost of pharmaceutical industries. The method comprises the steps: removing matters such as macromolecular particles, organic matters, colloid and the like in raw material liquid through microfiltration and ultrafiltration, and then carrying out salt leaching and concentration by a nanofiltration constant volume desalination technology, directly drying the desalted concentrated liquor in vacuum or moving to the next process, and finally carrying out the selective recovery according to the economic value of the matters contained in a permeating liquid. The method has the advantages of not only realizing the double effect of desalination and concentration, increasing the content of effective matters, but also being capable of recycling the useful matters in the permeating liquid and increasing the economic benefit.

Description

technical field [0001] The invention relates to a method for desalting and concentrating pharmaceutical intermediates, which can not only simplify the original operation process, but also obtain products with higher purity, and reduce the production cost of the pharmaceutical industry, belonging to the desalting and concentrating method of pharmaceutical intermediates technology field. Background technique [0002] At present, many pharmaceutical intermediates must adjust the pH many times in the production process to make the reaction fully proceed and obtain the highest yield. In the process of repeated acid-base adjustment, it will inevitably bring a considerable amount of salt, which will directly affect the quality of the product. Therefore, the product must be desalted. How to desalinate it in an efficient and easy way has become a lot of problems. A hotspot of concern and research by pharmaceutical manufacturers. With the continuous development of the economy, highe...

Claims

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Application Information

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IPC IPC(8): B01D61/58B01D71/34
Inventor 赵经纬邱晖姜新建沈斌夏金维
Owner HANGZHOU TIAN CHUANG ENVIRONMENTAL TECH
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