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Application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating non-small cell lung cancer

A non-small cell lung cancer and ginsenoside technology, which is applied in drug combinations, antineoplastic drugs, and pharmaceutical formulations, can solve the problems of non-small cell lung cancer with undiscovered drugs, and achieve the effect of prolonging the life cycle and improving the quality of life

Inactive Publication Date: 2010-06-16
北京鑫利恒医药科技发展有限公司
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Problems solved by technology

So far, no drug has been found to be effective in the treatment of non-small cell lung cancer

Method used

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  • Application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating non-small cell lung cancer
  • Application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating non-small cell lung cancer
  • Application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating non-small cell lung cancer

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Abstract

The invention relates to medicine application of 20(S)-ginsenoside Rg3, in particular to application of 20(S)-ginsenoside Rg3 in preparation of medicines for treating a non-small cell lung cancer. In the invention, selecting a human non-small cell lung cancer cell strain (A549 lung adenocarcinoma, H460 large cell lung cancer and LTEP-78 lung squamous carcinoma) to be inoculated under the skin of a naked mouse, and observing the influence of the SPG-Rg3 on the non-small cell lung cancer; and carrying out CD34 immunohistochemistry staining and TUNEL immunofluorescence staining on tumor tissues, and observing the influence of the SPG-Rg3 on tumor angiogenesis and apoptosis. The inclusion proves that the 20(S)-ginsenoside Rg3 can remarkably inhibit the growth of the non-small cell lung cancer, has the action mechanism related with the promotion of the tumor apoptosis and the inhibition of the tumor angiogenesis and unobvious cooperation action when being combined with cyclophosphamide for application, and can be used for the clinical chemotherapy of the non-small cell lung cancer.

Description

technical field The invention belongs to the field of drug research, and specifically relates to the application of 20(S)-ginsenoside Rg3 as a medicine for treating non-small cell lung cancer. Background technique Lung cancer is a common clinical malignant tumor, which is usually divided into two categories: small cell lung cancer and non-small cell lung cancer. Accounting for the vast majority, the most common, accounting for more than 80% of the total number of lung cancer. The incidence of non-small cell lung cancer is increasing year by year all over the world, which seriously threatens human health. The current treatment methods for NSCLC mainly include the following: (1) Surgical treatment of NSCLC At present, the most ideal method for the treatment of NSCLC is still surgical treatment. The purpose of surgical treatment is to remove the lung cancer lesion and regional lymph nodes, and to preserve as much healthy lung tissue as possible. At present, cryoablation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P35/00
Inventor 赵文杰倪劲松李平亚
Owner 北京鑫利恒医药科技发展有限公司
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