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Stabilized cysteamine growth promoting agent used for aquatic feeds and production method thereof

A growth-promoting agent and aquatic feed technology, which is applied in the field of aquatic animal growth agents and aquatic feed stabilized cysteamine growth-promoting agents, can solve problems such as incomplete coverage of cysteamine particles, chemical changes, and large specific surface area. Overcome the effect of being unsuitable for the aquafeed industry, and the product particle size is ultra-fine

Active Publication Date: 2010-06-02
GUANGDONG HAID GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cysteamine is a growth hormone inhibitor in animal nutrition and physiology. It can promote the growth of animals by regulating the secretion of somatostatin. A large number of experiments have proved that it is a safe and efficient drug for livestock, poultry and aquatic animals. However, in the actual feed production application, there is still a fatal shortcoming of poor stability, the main reason is that the active group -SH in the chemical structure of cysteamine is used to inhibit somatostatin in the feed production process It is easy to undergo chemical changes when exposed to heat, thus losing its proper physiological activity
For this reason, cysteamine preparations stabilized by coating processing have been developed. Its main features are: fluidized bed technology is used, and macromolecular materials such as cyclodextrin are used as coating materials to protect cysteamine from thermal processing of feed. influence, thereby maintaining stability, but this process based on granulation technology fundamentally determines that the average particle size of coated cysteamine is basically above the 20-mesh standard sieve, otherwise it may be due to the small size of the particles and the specific surface area Too large, so that the coating material cannot completely cover the cysteamine particles as the core material, and lose the protective function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 10,000ml of water to the three-neck reaction flask, add 890g of zinc sulfate monohydrate while stirring, control the temperature at 45°C, continue stirring for 15 minutes, add 590g of cysteamine hydrochloric acid, stir until the solution is clear, add 380g of silicon dioxide , stirred for 30 minutes, turned to a rotary evaporator and concentrated in vacuum at 60°C until the solids concentration was 20%, and then spray-dried. The moisture content of the product is 6%, and the fineness passes through a 100-mesh standard sieve. The yield is about 83%.

Embodiment 2

[0026] Add 600ml of water to the three-neck reaction flask, add 143 grams of zinc sulfate heptahydrate while stirring, control the temperature at 40°C, continue stirring for 20 minutes, add 59 grams of cysteamine hydrochloric acid, stir until the solution is clear, add 80 grams of silicon dioxide , stirred for 30 minutes, and spray-dried directly, the inlet air temperature was 190°C to 200°C, and the outlet air temperature was 80°C to 100°C. The moisture content of the product is 7.5%, and the fineness passes through a 100-mesh standard sieve. The yield is about 86%.

Embodiment 3

[0028] Add 20000ml of water to the three-neck reaction flask, add 905g of zinc sulfate monohydrate while stirring, control the temperature at 40°C, continue stirring for 15 minutes, add 590g of cysteamine hydrochloric acid, stir until the solution is clear, add 400g of silicon dioxide , stirred for 30 minutes, transferred to a rotary evaporator and concentrated in vacuum at 60°C until the solids concentration was 18%, followed by spray drying, the inlet air temperature was 190°C-200°C, and the outlet air temperature was 80°C-100°C. The moisture content of the product is 7.5%, and the fineness passes through a 100-mesh standard sieve. The yield is about 85%.

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Abstract

The invention relates to a growth agent for aquatic animals and a production method thereof, in particular to a stabilized cysteamine growth promoting agent used for aquatic feeds and a production method thereof, belonging to the technical field of feed additive production. The stabilized cysteamine growth promoting agent used for the aquatic feeds comprises raw materials of cysteamine hydrochloride and monohydrate zinc sulphate or heptahydrate zinc sulphate with the mass ratio of 1:1-1:3. The production method comprises the following steps of: mixing the cysteamine hydrochloride, the monohydrate zinc sulphate or the heptahydrate zinc sulphate, and water based on the mass ratio, and enabling the temperature of the mixed solution to be constantly at 40-50 DEG C; after the cysteamine hydrochloride and the zinc sulphate dissolve in the water, adding silicon dioxide and stirring for 20-90 minutes; and drying the mixed solution to be with 5-12 percent of moisture. The product of the invention has superfine product particle-size while ensuring the stability of the cysteamine, and overcomes the difficulty that traditional encapsulated type stabilized cysteamine agent is not suitable for aquatic feeds industry, wherein average particle size is smaller than 100 mesh standard sieve.

Description

【Technical field】 [0001] The invention relates to an aquatic animal growth agent and a production method thereof, in particular to a stabilized cysteamine growth promoter suitable for aquatic feed and a production method thereof. The invention belongs to the technical field of feed additive production. 【Background technique】 [0002] Aquaculture is the fastest-growing industry in my country's new rural economy. It plays an extremely critical role in helping farmers get rid of poverty and improve their living conditions. Scientifically and rationally increasing the growth rate of aquatic animals and reducing feed waste, regardless of the realization of reducing aquaculture pollution The sustainable development of aquaculture and the improvement of the economic benefits of aquaculture all play a very significant role. Cysteamine is a growth hormone inhibitor in animal nutrition and physiology. It can promote the growth of animals by regulating the secretion of somatostatin. A ...

Claims

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Application Information

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IPC IPC(8): A23K1/18A23K1/16A23K20/142A23K20/20A23K50/80
Inventor 钱雪桥
Owner GUANGDONG HAID GROUP
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