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Temperature sensitive wound face dressing film and preparation method thereof

A sensitive and wound technology, applied in the fields of medical science, bandages, absorbent pads, etc., to achieve the effect of improving curative effect, good water absorption, and protection from pollution

Inactive Publication Date: 2012-10-31
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This temperature-sensitive wound dressing has not been reported so far

Method used

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  • Temperature sensitive wound face dressing film and preparation method thereof

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Effect test

Embodiment 1

[0020] Embodiment 1: The following is an example of preparing a novel temperature-sensitive wound dressing in the present invention, and its technological process and steps are as follows:

[0021] 1. Take 20g of PVA powder and put it in a beaker, then add 180g of deionized water, stir while heating in a 90°C water bath until the PVA is completely dissolved to obtain a 10% (w / w) PVA solution, and cool it at room temperature for later use.

[0022] 2. Measure 5ml of glacial acetic acid, and dilute to volume in a 500ml volumetric flask to prepare 500ml of 1% HAc solution. Weigh 3g of CS powder and dissolve it with 150ml 1% HAc solution. After the solid is completely dissolved, add 3g of NIPAAm monomer and stir until completely dissolved. Pour the mixed solution into a three-necked bottle, pre-filled with N at room temperature 2 40 minutes. Weigh 0.0100g of KPS, dissolve it with 1ml of deionized water, add it dropwise into a three-neck flask, and after the addition is complete,...

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Abstract

The invention relates to a temperature sensitive wound face dressing film and a preparation method thereof, which belongs to the technical field of biologic medical high molecular materials. In the method, vinyl alcohol (PVA) and a glycan-grafted N-isopropyl acylamide polymer (CS-g-PNIPAAm) are mixed together, then the procedures of injection molding, dried filming, sterilization and the like arecarried out, and finally, the temperature sensitive wound face dressing film with the function of slow release is prepared. The gel dressing film combines the original advantages of polyvinyl alcoholand chitosan, has better transparence, water absorptivity and humidity preservation property, is not conglutinated with regenerated tissues and can effectively prevent the infection of a wound face. When being used, the dressing film carrying a medicine generates reversible swelling and contraction along with the temperature change of the wound face by medicine carrying, and the medicine generates circular opening and closing release along with the dressing film, thereby achieving the intellectualized control of the release of the medicine, promoting the healing of the wound face and enhancing the curative effect.

Description

technical field [0001] The invention relates to a temperature-sensitive wound dressing and a preparation method thereof, belonging to the technical field of biomedical polymer materials. Background technique [0002] Burns and scalds are not uncommon in daily life. Due to the different depths and orientations of the formed wounds, if traditional medical gauze or cotton yarn dressings are used for treatment, it will not only easily cause wound infection, but also cause various complications, resulting in systemic infection Symptoms; and the recovery period is long, it is easy to cause secondary damage; problems such as obvious scars after wound recovery have plagued countless patients, which shows that the effect of the repair stage of traditional treatments is often not satisfactory. If the wound surface covering (or coating) has the function of antibacterial, hemostatic, moisturizing, hydrophilic, non-adhesive to new tissue, and can release drugs according to the situation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/60A61L15/62A61L15/44
Inventor 陈捷邬慧凤杨黎明倪俊赵甜静赵欣雄
Owner SHANGHAI UNIV
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