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Application of elemene in preparing medicine for resisting postoperation restenosis and stent restenosis after PTCA

A technology of restenosis and elemene is applied in the application field of elemene in the preparation of anti-PTCA postoperative restenosis and in-stent restenosis drugs, which can solve the problems such as no reports on the application of elemene, and achieve prevention and control. Highly effective, significant restenosis and in-stent restenosis, and proliferation-inhibiting effects

Inactive Publication Date: 2010-05-12
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Elemene is a mixture of elemenes, the main component is β-elemene, and it also contains a small amount of γ-elemene and δ-elemene. Pharmacological and clinical trials have proved that it has a definite curative effect on tumors , but so far there is no report on the application of elemene in the preparation of anti-PTCA postoperative restenosis and in-stent restenosis drugs

Method used

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  • Application of elemene in preparing medicine for resisting postoperation restenosis and stent restenosis after PTCA
  • Application of elemene in preparing medicine for resisting postoperation restenosis and stent restenosis after PTCA
  • Application of elemene in preparing medicine for resisting postoperation restenosis and stent restenosis after PTCA

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Embodiment Construction

[0015] The effect of elemene on post-PTCA restenosis and in-stent restenosis will be described in detail below with reference to the accompanying drawings.

[0016] 1. Effect of elemene on the proliferation and migration of rat cardiac aortic smooth muscle cells

[0017] Vascular smooth muscle cells (VSMCs) are the major cellular components of the vessel wall. In the process of restenosis, the phenotype of VSMCs changes from contractile to synthetic, and the synthetic VSMCs have a strong ability to proliferate, and the proliferating VSMCs migrate from the media to the intima, resulting in a large amount of VSMCs in the intima. tissue formation, thereby promoting neointima formation. Therefore, the proliferation and migration of VSMCs is the main pathological mechanism of vascular intimal hyperplasia, and inhibiting the proliferation and migration of VSMCs is the central link in inhibiting intimal hyperplasia.

[0018] Experimental materials: Elemene (purity ≥ 98.2%, purchase...

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Abstract

The invention discloses an application of elemene in preparing medicine for resisting postoperation restenosis and stent restenosis after PTCA. Discovered in experiments and research, elemene can restrain blood vessel smooth muscle cells from proliferation and migration, can restrain blood vessel endothelial cells from proliferation, has protective action on oxidative damaged endothelial cells, can alleviate intima proliferation degree of experimental restenosis animal models and reduce restenosis rate, has remarkable action in resisting postoperation restenosis and stent restenosis after PTCA, and can be applied in preparing medicine for resisting postoperation restenosis and stent restenosis after PTCA or further preparing medicinal coating brackets, thus providing an efficient, safe and economic solution for preventing and curing postoperation restenosis and stent restenosis after PTCA.

Description

technical field [0001] The invention relates to a new application of a medicine, in particular to the application of elemene in the preparation of anti-PTCA (percutaneous transluminal coronary angioplasty) postoperative restenosis and intrastent restenosis medicine. Background technique [0002] Coronary heart disease is a kind of heart disease caused by myocardial ischemia hypoxia or myocardial necrosis caused by organic stenosis or obstruction of coronary artery. Due to its high morbidity and mortality, it seriously endangers human health. [0003] Since the first report by Gruenzig et al. in 1977 on the use of PTCA for interventional treatment of coronary heart disease, PTCA and related technologies have gradually matured and become one of the main methods for the treatment of coronary heart disease, and have been widely used clinically. However, the incidence of restenosis in 3 to 6 months after PTCA is as high as 30% to 50%, which seriously affects the medium and long-t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/015A61P9/10A61L31/08A61L31/16
Inventor 王贵学凌博唐舒棠尹铁英唐朝君黄俊丽
Owner CHONGQING UNIV
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