Culture box for producing tissue engineering skin

Abstract

The invention relates to a culture box for producing tissue engineering skin. The culture box comprises a bottom box with a liquid-changing groove, a box cover and culture brackets, wherein the culture brackets are spread in a single layer in the bottom box. When using the culture box of the invention, the box cover is only needed to be opened three times during the whole culture period so as to greatly reduce the probability that the product is polluted and largely increase the reliability during the culture process; during culture and production process, the culture space can be saved, the operation sequences can be reduced and the production efficiency can be increased so as to greatly reduce the production cost and realize mass production; the standardized production and operation are easy to realize and the product quality is very stable; and the culture box of the invention has lighter weight, is not easy to break up, and can realize automatic or semi-automatic manipulator operation during the culture and production of the tissue engineering skin, dramatically reduce the labor intensity, increase the production efficiency and provide the basis for the mass production of the tissue engineering skin.

Description

technical field [0001] The invention belongs to an appliance device in the technical field of tissue engineering, and in particular relates to the improvement of the structure of a culture box used for tissue engineering skin production. Background technique [0002] At present, there are few equipment and utensils dedicated to the production of tissue engineering products, and the traditional utensils for tissue engineering skin culture are mainly glass culture dishes, which are all produced by hand. The use of glass petri dishes in the production of tissue-engineered skin has the following defects: ① During the entire culture and production, it is necessary to open the lid of the petri dish dozens of times for liquid replacement operations. Frequent opening of the lid may easily cause the product to be contaminated by microorganisms and dust in the air The probability of particle pollution increases; according to statistics, in a 100-level clean environment, about 30% of t...

AI Technical Summary

Problems solved by technology

The use of glass petri dishes in the production of tissue-engineered skin has the following defects: ① During the entire culture and production, it is necessary to open the lid of the petri dish dozens of times for liquid replacement operations. Frequent opening of the lid may easily cause the product to be contaminated by microorganisms and dust in the air The probability of particle pollution increases; according to statistics, in a 100-level clean environment, about 30% of the products are unqualified due to pollution, and this kind of unqualified due to pollution cannot be eliminated at present, so the production cost increases

②Due to the characteristics of the structure of the glass petri dish, the manual production method of one box and one operation makes the skin production process complicated, the utilization rate of the cultivation space is low, the standardization of the production process cannot be achieved, and it is difficult to ensure the uniformity of product quality. The qualified rate is hovering at 60%-65%, and the production cost is difficult to reduce

③Because the glass petri dish is brittle and fragile, it is difficult to apply automatic operation in production, and only manual operation can be used; while in the production and cultivation process of skin, the petri dish needs to be transported and opened many times, and the labor intensity is very high. If you don't pay attention, it will be broken, the production efficiency is low, and it is difficult to carry out standardized operation and large-scale production, which hinders the process of tissue engineering skin products to the market and limits the rapid development of the tissue engineering industry.

[0004] After searching, there is no public report on relevant products and materials

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