Nontoxic polyethoxysiloxane material for the production of biologically resorbable and/or bioactive articles containing polyethoxysiloxane material, the production thereof, and the use thereof

Abstract

The present invention relates to a polyethoxysiloxane (PES) material to be obtained in that (a) a first hydrolysis condensation reaction of a maximum of one group X of one or more different Si compounds of the formula (I) SiX4 (I) in which the groups X are the same or different and represent hydroxy, hydrogen, or ethoxy (EtO), are catalyzed in an acidic fashion at an initial pH value of 0 to ≦̸7, is conducted in the presence of ethanol (EtOH) or an ethanol-water mixture as a solvent over a time period of 1 to 24 hours at a temperature of 0° C. to 78° C, (b) a second hydrolysis condensation reaction of the material obtained in step (a) is conducted while simultaneously removing the solvent by successive evaporation in a gas diffusion-tight container at a pressure of 100 to 1013 mbar, preferably at a slight negative pressure of 300 mbar to 800 mbar and a temperature of 50-78° C. until a drastic increase in viscosity (at a shear rate of 10 s−1 at 4° C.) to 0.5 to 2 Pa·s until a constant weight is attained and a cyclotetrasiloxane of the general formula ((SiO(OH)0,75(OEt)1,25× 1 / 64H2O)4 and a molar mass of 4*approx. 114 g=approx. 456 g; (c) said PES material is cooled in a closed container over a time period from a few minutes to a few hours, and (d) the PES material obtained from step (c) is converted into an rPES material by a third hydrolysis condensation reaction.

Description

technical field [0001] The present invention relates to a non-toxic polyethoxysiloxane material (PES material), if desired a cured polyethoxysiloxane material (rPES material), preferably in the form of a number of different polyethoxysiloxane Form composition of one of the materials (PES material). According to the invention, the rPES material (r stands for ripening) can be spun, for example, as a PES material into bioresorbable and / or bioactive fibers; and then further processed into a web as other PES material. The invention also relates to methods for the manufacture of cured-on-demand PES materials, bioresorbable and / or bioactive PES materials, and uses of these materials. Background technique [0002] Various efforts are currently being made to develop bioresorbable materials for various applications in human medicine and medical technology, but also in other technical fields such as filtration technology, biotechnology or insulation materials industry. Furthermore, ...

AI Technical Summary

Problems solved by technology

[0004] Furthermore, the disadvantage of the fiber production process according to DE 196 09 551 C1 is that, in the hydrolytic condensation step, the resulting mixture after removal of the solvent is a heterogeneous mixture, which must be filtered to remove the solid matter formed

Other liquid silicone polymers can be toxic but cannot be removed by filtration at all

Furthermore, a large proportion of the spinnable sol is lost, especially due to the formation of a solid phase and the mandatory filtration step