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Hydrogel controlled by hydrogen bond and pi-pi accumulation biswitch and preparation and application thereof

A hydrogel, π stacking technology, applied in the field of drug controlled release system research, can solve the problem of inability to match drug metabolism

Active Publication Date: 2010-03-17
江苏先进无机材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current synthetic drug controlled release system cannot match the drug release with the metabolism of the human metabolic system.

Method used

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  • Hydrogel controlled by hydrogen bond and pi-pi accumulation biswitch and preparation and application thereof
  • Hydrogel controlled by hydrogen bond and pi-pi accumulation biswitch and preparation and application thereof
  • Hydrogel controlled by hydrogen bond and pi-pi accumulation biswitch and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] 1. Preparation of functional monomers

[0024] (1) p-nitrophenol methacrylate

[0025] Dissolve methacryloyl chloride, p-nitrophenol and triethanolamine (1:1:1 molar ratio) in chloroform, stir and react for 5-60 hours at a low temperature of -10-5°C (such as an ice-water bath), and wash with saturated NH 4 Cl ends the reaction, and the reaction product is recrystallized from ethanol to obtain white crystals. The resulting product is dried below 100°C for future use.

[0026] (2) p-nitrophenol acrylate

[0027] Dissolve acryloyl chloride, p-nitrophenol and triethanolamine (1:1:1 molar ratio) in chloroform, stir and react at a low temperature of -10 to 5°C (such as an ice-water bath) for 5 to 60 hours, and wash with saturated NH 4 Cl ends the reaction, and the reaction product is recrystallized from ethanol to obtain white crystals. The resulting product is dried below 100°C for future use.

[0028] The proton magnetic resonance spectrum of the product that the synth...

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Abstract

The invention relates to a PMAA and PAA base hydrogel which has a sequential lamellar structure and is prepared from aryl monomer having a pi-pi accumulation function and carboxyl monomer having a hydrogen bond function. The hydrogel of the invention controls a drug release system by a hydrogen bond and a pi-pi accumulation biswitch and realizes continuous regulation of drug release; the gel swelling property test shows that the hydrogel of the invention has favorable pH responsiveness; the drug release experiment stimulating a human body metabolic system shows that the drug release control system prepared by the hydrogel of the invention can match drug release and the human body metabolic system and effectively reduces drug waste and side effect on the human body by excessive drug.

Description

technical field [0001] The invention relates to the research field of drug controlled release systems, in particular to hydrogel materials, and more specifically to hydrogels controlled by double switches of hydrogen bonds and π-π stacking, and their preparation and application. Background technique [0002] Controlled-release local drug delivery and targeted drug delivery technology can solve the problems of sudden release, short drug release time, cytotoxicity and non-selective release of drugs in traditional drug delivery methods, and has become an important development of drug therapy. one of the directions. Polymer hydrogels with environmental responsive properties are a hotspot in the field of controlled drug release. [0003] Both polyacrylic acid (PAA) and polymethacrylic acid (PMAA) hydrogels are important pH-responsive hydrogels due to their good physicochemical stability, controllable mechanical Due to the sharp phase transition phenomenon, it is widely used as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/00A61K31/192A61P29/00
Inventor 祝迎春李芳
Owner 江苏先进无机材料研究院
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