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Focused ultrasound-polymeric micelle controllable drug release device and release method thereof

A technology of focused ultrasound and polymer glue, which is applied in drug delivery, pharmaceutical formulations, and drug devices, can solve the problems of increased release rate and achieve the effect of convenient operation and strong controllability

Inactive Publication Date: 2010-01-06
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This technology allows remote control over how much medicine will stay inside your body without being affected with external factors like heat or pressure from outside during treatment sessions. It also enables precise placement within specific areas where medications are needed throughout an entire session while maintaining their effectiveness through controlled delivery methods such as ultrasonic waves.

Problems solved by technology

This patents describes various techniques related to improving the delivery and activation of nanoplasma particles during medical applications like imaging and therapeutronics. These include laser irradiation, ultramicroscopy, X ray absorption spectroscopy and magnetic resonant scattering. Sonothermoson Microspheres (SPUMs) provide excellent results due to its ability to create stable gas mixtures within solid materials. Additionally, these methods involve applying ultrasounds to trigger molecular interactions inside small spherons containing hydrophobia solvents.

Method used

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  • Focused ultrasound-polymeric micelle controllable drug release device and release method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The focused ultrasound-polymer micelle controllable drug release device is composed of a focused ultrasound system and a drug-loaded polymer micelle system. The focused ultrasound system is connected by a signal generator 1 through a power amplifier 2 and a focused ultrasound transducer 3, and the drug is loaded and polymerized. The micelle system is composed of a compound micelle 5 formed by an amphiphilic block copolymer and a drug and a medium 4. The drug-loaded polymer micelle is provided with a sensor 6, and the sensor is connected to a computer 8 through a signal processor 7.

[0042] Focused ultrasound-polymer micelles controlled drug release method includes the following steps:

[0043] (1) Preparation of polyethylene glycol-b-polylactic acid (PEG-b-PLA) / fluorescent dye Nile Red (NR) composite micelles:

[0044] Dissolve 10 mg of Nile Red (NR) in 50 mL of tetrahydrofuran (THF) to prepare a NR / THF solution with a concentration of 0.2 mg / mL, and then add 500 mg of...

Embodiment 2

[0048] Focused ultrasound device is the same as embodiment 1

[0049] (1) Polyoxyethylene / poly(tetrahydropyranyl methacrylate) copolymer (PEO 112 -b-PTHPMA 164 ) / paclitaxel polymer micelles preparation:

[0050] Dissolve 2 mg of paclitaxel in 50 mL of tetrahydrofuran (THF) to prepare a paclitaxel / THF solution with a concentration of 0.04 mg / mL, and dissolve 1.3 mg of PEO 112 -b-PTHPMA 164 The block copolymer was dissolved in 10 mL of the above solution, and 5 mL of distilled water was added dropwise with stirring. After the dropwise addition, continue to stir for 3 hours, and then add 15 mL of distilled water dropwise to the solution. At this time, the Nile red that has not solubilized into the inner core of the micelles will precipitate from the solution. 8000-14400 dialysis bags remove THF from the system, and finally filter to remove paclitaxel that has not solubilized into the inner core of micelles. The polymer concentration of the obtained micellar solution was 0.06...

Embodiment 3

[0054] Focused ultrasound device is the same as embodiment 1

[0055] (1) Polyethylene oxide / polytetrahydrofuryl methacrylate copolymer (PEO 112 -b-PTHFMA 90 ) / preparation of curcumin composite micelles:

[0056] Weigh 5mg curcumin and dissolve it in dry 50mL THF solvent, the concentration is 0.1mg / mL, 1mgPEO 112 -b-PTHFMA 90 Dissolve in 10mL of the above solution, and add 10mL of distilled water dropwise under stirring. Continue to stir for 3 hours after the dropwise addition, and then add 10 mL of distilled water dropwise to the solution. At this time, the curcumin that has not been solubilized into the inner core of the micelles is precipitated from the solution, and the THF in the system is removed under stirring at a temperature of 45° C. Solubilization of curcumin into the micellar core. The polymer concentration of the obtained micellar solution was 0.05 mg / mL, and the weight ratio of the drug to the block polymer was 0.8. The size of the composite micelles was ~3...

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Abstract

The invention discloses a focused ultrasound-polymeric micelle controllable drug release device and a release method thereof. The device is characterized by consisting of a focused ultrasound system and a drug loaded polymeric micelle system, wherein the focused ultrasound system is connected with a focused ultrasound energy converter (3) by a signal generator (1) through a power amplifier (2); the drug loaded polymeric micelle system consists of a complex micelle (5) formed by amphiphilic block copolymers and drugs and a medium (4); and a drug loaded polymeric micelle is internally provided with a sensor (6) which is connected with a computer (8) through a signal processor (7). The focused ultrasound-polymeric micelle controllable drug release method comprises the step that the drug carried polymeric micelle is prepared through a dialysis method or a solvent evaporation method, and under ultrasonic irradiation, the polymeric micelle responds to ultrasound through a physical or chemical change so as to ensure that loaded hydrophobic drugs are released from the micelle and enter a focal part.

Description

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Claims

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Application Information

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Owner SICHUAN UNIV
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