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Compound sodium sulfadimidine injection liquid for pig and preparation method thereof

A technology of sulfamethazine sodium and injection, which is applied in the field of compound sulfamethazine sodium injection and its preparation for pigs, and can solve the problem of poor treatment effect of ordinary single drug, inability to quickly and effectively treat diseases, and strong resistance of pathogens Drug properties and other issues, to achieve the effect of treating and preventing bacterial secondary infection, reducing the chance of drug resistance, and strengthening the effect of anti-pathogenic microorganisms

Inactive Publication Date: 2009-12-23
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the common occurrence of this disease in recent years, the flooding of drugs, the strong drug resistance of pathogens, the poor effect of ordinary single drug treatment, and the inability to quickly and effectively treat the disease due to no symptomatic treatment, or only symptomatic treatment, resulting in The death of pigs has brought great losses to the farmers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Take 30L of water for injection, add 0.2kg of sodium sulfite and 0.01kg of EDTA-2Na, stir to dissolve, then add 5kg of sulfamethazine sodium, and stir until completely dissolved.

[0020] (2) Take 40kg of propylene glycol, heat to about 80°C to dissolve 1kg of trimethoprim, 10kg of lincomycin hydrochloride, and 20kg of aminopyrine, and cool to about 50°C after all are dissolved.

[0021] (3) Combine the solution prepared in step (1) and step (2), add 10 kg of 95% ethanol, then add water for injection to 100 L, stir evenly, keep for 15-20 min, and use a mass percentage concentration of 40% sodium hydroxide The solution or the hydrochloric acid solution with a concentration of 10% by volume is adjusted to a pH value of 10.22, and the compound sulfamethazine sodium injection for pigs of the present invention is prepared after the medicinal liquid becomes clear.

Embodiment 2

[0023] (1) Take 30 L of water for injection, add 0.2 kg of sodium sulfite and 0.01 kg of EDTA-2Na, stir to dissolve, then add 20 kg of sulfamethazine sodium, and stir until completely dissolved.

[0024] (2) Take 40kg of propylene glycol, heat to about 80°C to dissolve 4kg of trimethoprim, 1kg of lincomycin hydrochloride, and 5kg of aminopyrine, and cool to about 50°C after all are dissolved.

[0025] (3) Combine the solution prepared in step (1) and step (2), add 10 kg of 95% ethanol, then add water for injection to 100 L, stir evenly, keep for 15-20 min, and use a mass percentage concentration of 40% sodium hydroxide The pH value of the solution or the hydrochloric acid solution with a concentration of 10% by volume is adjusted to 10.55, and the compound sulfamethazine sodium injection for pigs of the present invention is prepared after the medicinal liquid becomes clear.

Embodiment 3

[0027] (1) Take 30L of water for injection, add 0.2kg of sodium sulfite and 0.01kg of EDTA-2Na, stir to dissolve, then add 8kg of sulfamethazine sodium, and stir until completely dissolved.

[0028] (2) Take 40kg of propylene glycol, heat to about 80°C to dissolve 1.6kg of trimethoprim, 7kg of lincomycin hydrochloride, and 15kg of aminopyrine, and cool to about 50°C after all are dissolved.

[0029] (3) Combine the solution prepared in step (1) and step (2), add 10 kg of 95% ethanol, then add water for injection to 100 L, stir evenly, keep for 15-20 min, and use 40% sodium hydroxide solution with a mass percentage concentration Or adjust the pH value to 10.65 with a hydrochloric acid solution with a concentration of 10% by volume, and make the compound sulfamethazine sodium injection for pigs of the present invention after the liquid is clarified.

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Abstract

The invention discloses a compound sodium sulfadimidine injection liquid for a pig and a preparation method thereof, aiming at providing a compound kanamycin sulfate injection liquid which has fast effect for treating toxoplasmosis of the pig, addresses both the symptoms and root causes, reduces the time and dosage of used drug and has convenient drug usage, and a preparation method with simple technique and easy implementation. Each 100L injection liquid comprises: 5 to 20 sodium sulfadimidine, 1 to 10kg of lincomycin hydrochloride, 5 to 20kg of doxofylline, 1 to 4kg of trimethoprim, 0.2kg of sodium bisulfite, 0.01kg of EDTA-2Na, 40kg of propylene glycol, 10kg of 95% alcohol and the balance of water for injection. The injection liquid has fast effect for toxoplasmosis of the pig, addresses both the symptoms and root causes, can effectively treat and prevent secondary infection of bacterium, reduces drug resistance of pathogenic microorganism and leads the pig to accelerate restoring. Simultaneously, the compound sodium sulfadimidine injection liquid is an injection liquid and has convenient use.

Description

technical field [0001] The invention relates to a compound sulfamethazine sodium injection for pigs and a preparation method thereof. Background technique [0002] Toxoplasma porcini infection is a common disease in pigs. The main clinical manifestations are high fever, depression, dyspnea, obvious enlarged lymph nodes, blood spots on the lower part of the body and ear tips, or large areas of cyanosis. With the prolongation of the disease, it is easy to continue. Other bacterial infections occur, the disease is highly contagious and has a high mortality rate. [0003] Due to the common occurrence of this disease in recent years, the flooding of drugs, the strong drug resistance of pathogens, the poor effect of ordinary single drug treatment, and the inability to quickly and effectively treat the disease due to no symptomatic treatment, or only symptomatic treatment, resulting in The death of pigs brings great losses to the farmers. Contents of the invention [0004] The ...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K31/635A61K31/505A61K31/4152A61K9/08A61P31/04A61P29/00
Inventor 徐克福
Owner TIANJIN SHENGJI GRP CO LTD
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