Biosensor with evanescent waveguide and integrated sensor

A sensor and waveguide technology, which is applied in the field of chemical or biological sensors for detecting biomolecules, can solve problems such as complex positioning, complex coating layers of nanowell microarrays, etc., and achieve the effect of minimizing internal reflections

Inactive Publication Date: 2009-12-16
KONINK PHILIPS ELECTRONICS NV
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Problems solved by technology

Fabrication of this nanowell microarray cladding requires a more complex and precise process
In addition, very small nanowells require more precise and more complex positioning of binding molecules within all wells, leading to additional defects
Furthermore, said prior art evanescent field waveguide biosensors do not have an integrated optical filter sandwiched between the waveguide layer and the sensor

Method used

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  • Biosensor with evanescent waveguide and integrated sensor
  • Biosensor with evanescent waveguide and integrated sensor
  • Biosensor with evanescent waveguide and integrated sensor

Examples

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Embodiment Construction

[0129] figure 1 A sensor system 1 for evanescent field sensing that can be used for diagnostic applications is shown with a housing 2 . The housing is placed over the integrated waveguide sensor 3 . The integrated waveguide sensor 3 includes a polymer waveguide layer 4 above the cladding layer 7, wherein the polymer waveguide layer 4 is made of polyethersulfone (PES), its thickness is 250nm, and its refractive index n2=1.65, the cladding layer 7 Made of polymethyl methacrylate (PMMA), its thickness is 1 mm, and its refractive index is n3 = 1.49. On the upper outer surface 6 of the polymer waveguide layer 4 capture compounds 5 are provided for detection of specific chemical species. On the upper and outer surface of the polymer waveguide layer 4, a grid structure consisting of a plurality of depressions 18 is provided for enhancing the coupling of light waves into the transparent polymer waveguide. Alternatively, a grid structure may also be present at the interface between...

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Abstract

the present invention is directed to a waveguide sensor as well as to an evanescent field induced evanescent field induced sensor systemfor use in diagnostic applications that comprises a housingand an integrated waveguide sensor comprising: a waveguide layer, -capture compounds applied on the upper surface of said waveguide layer for specific bonding to target substances, -a cladding layer contacting arranged on the lower surface of said waveguide layer, -a filter which is transmitting for luminescent radiation while absorbs and / or reflects radiation of excitation radiation, wherein the filter is arranged below the lower surface of said cladding layer, at least one detector for sensing luminescent radiation, wherein the detector is arranged below the lower surface of said filter, a substrate that is connected with the detector and comprises the electrical interface of said detector; wherein between the upper surface of the waveguide layerand along at least a lower surface section of the housing a channel is formed for receiving a fluidic probe; and the luminescent radiation is generated by luminescent tag bound to target substances as a result oftheir excitation by the evanescent field. This provides an improved sensitivity of the evanescent field induced sensor system.

Description

technical field [0001] The present invention relates to sensor systems based on evanescent fields. More specifically, the present invention relates to sensor systems with evanescent waveguides and integrated detectors for use as chemical or biological sensors for the detection of biomolecules. Background technique [0002] Evanescent luminescence excitation is of great interest in the analytical field because the excitation is confined to the immediate environment of the waveguide layer. In particular, evanescent field-excited fluorescence is a very important technique for biosensors due to its unique sensitivity. [0003] An important advantage of detecting bound fluorescent molecules excited by evanescent waves is that the emitted fluorescence can be detected outside of the aqueous reaction solution. Most complex biological solutions contain molecules that interfere with fluorescence emission. This means that when a fluorescent molecule is excited it emits photons, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
CPCG01N21/7703G01N21/648G01N21/6454
Inventor R·温伯格弗里德尔N·D·扬P·J·范德扎格
Owner KONINK PHILIPS ELECTRONICS NV
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