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Selenium-threonine and preparation method and application thereof

A technology of threonine and selenium dioxide, which is applied in the fields of application, cyanide reaction preparation, chemical instruments and methods, etc., can solve the problems of difficult solubility of solid threonine, complicated operation process, low biological titer, etc. To achieve the effect of improving feed remuneration, improving growth performance and high biological titer

Active Publication Date: 2009-12-09
XINGJIA BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, inorganic salts of selenium are mostly used as feed additives. Animals must pass through various biological barriers for absorption and utilization. The absorption rate is low, the addition amount is large, and the biological potency is low. The activity of other nutrients (such as vitamins, etc.) has a destructive effect
There is also the use of solid threonine and inorganic selenium as additives, but the operation process is complicated, and the solubility of solid threonine is relatively difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A threonine selenium finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve to replace the air in the reactor, then under the protection of nitrogen, first take 23.74g threonine and put it into a container filled with 100g reaction water. Fully stir in the reactor, then drop into 5.53g of selenium dioxide, adjust the pH value of the reaction mixture to 6.2 with sodium hydroxide at a temperature of 90°C, react for 2.5 hours under normal pressure conditions, then extract the reaction product with ethanol for 20 minutes, The volume ratio of ethanol to the reaction product is 10:1, and the extracted precipitate is dried in a flash at 120° C., crushed and then prepared to obtain the finished product of threonine selenium.

[0027] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the above reaction products, and the values ​​are all above 80%.

[0028] ...

Embodiment 2

[0034] A threonine selenium finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve to replace the air in the reactor, then under the protection of nitrogen, first take 198Kg threonine and put it into the reaction tank containing 1000Kg reaction water Fully stir in the kettle, then drop into 46Kg selenium dioxide, adjust the pH value of the reaction mixture to 6.4 with sodium hydroxide at a temperature of 90° C., react for 2 hours under normal pressure conditions, then send the reaction product to the concentration tank. kgf / cm 2 The vacuum degree and temperature are 90°C and vacuum concentration for 45 minutes. After the product is viscous, the concentrate is fed and put into a tray, flashed and dried at 110°C, and crushed to prepare the finished product of threonine selenium.

[0035] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product of the above reaction p...

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PUM

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Abstract

The invention discloses a threonine chelate of selenium-threonine and the preparation method comprises the following steps: mixing the selenium dioxide with threonine aqueous solution according to a mole ratio of (0.9-1.1):4 to react at 60-100 DEG C and with a pH value of 4-8 for 0.5-6h under protection of inert gas and obtaining a reaction product; vacuum concentrating or extracting the reaction products with an organic solvent, drying and crushing to obtain the finished product selenium-threonine. The selenium-threonine of the invention can be used as the animal feed additive so that the aim to effectively promote the growth of the animal, strengthen the resistance of the animal and improve the utilization efficiency of animal feed can be realized.

Description

technical field [0001] The invention relates to a feed additive and a preparation method thereof, in particular to an amino acid chelate compound, a preparation method and application thereof. Background technique [0002] Threonine is an important nutritional enhancer, which can strengthen the nutrition of grains, cakes, dairy products, etc. Threonine, like tryptophan, also has the functions of restoring human fatigue and promoting growth and development. In medicine, because the structure of threonine contains hydroxyl groups, it has a water-holding effect on human skin. After combining with oligosaccharide chains, it can play an important role in protecting cell membranes; threonine can also promote phospholipid synthesis and fatty acid oxidation in the body , and its preparation has medicinal effects such as promoting human growth and anti-fatty liver, and is often used as a component of compound amino acid infusion. At the same time, threonine is also the basic raw ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/76C07C229/22C07C227/16A23K1/16A23K20/142A23K20/20A23K50/30
Inventor 黄逸强
Owner XINGJIA BIO ENG CO LTD
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