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Method for changing viscosity of Magnolia extractive

An extract, Magnolia officinalis technology, applied in the field of changing the viscosity of Magnolia officinalis extract itself, can solve the problems of increased viscosity, inconvenient production, difficult production and the like, and achieves the effects of small dosage, easy operation and control, and low cost.

Active Publication Date: 2009-12-02
TIANJIN CENT PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The viscosity of Chinese medicine extracts is too high, which is not conducive to the concentration, drying and crushing of Chinese medicine extracts, which seriously restricts the subsequent preparation process
During the production process, due to some special properties of traditional Chinese medicine, it is inconvenient or even difficult to produce this variety.
For example, in the extraction of magnolia officinalis, as the amount of solvent in the liquid extract decreases during the concentration process, the viscosity increases accordingly, which causes great difficulty in the production of subsequent preparation processes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Get 600g Magnolia officinalis and use 6000ml 50% ethanol, reflux extraction 3 times, each 2 hours, filter, combine filtrate, concentrate under reduced pressure to thermal measurement relative density to be 1.2-1.3, obtain 76g of Magnolia officinalis extract dry matter. Add 25g of β-cyclodextrin, mix thoroughly, and vacuum dry to obtain a loose and non-sticky dry paste.

Embodiment 2

[0025] Get 600g Magnolia officinalis and use 4800ml 70% ethanol, reflux extraction 2 times, 3.5 hours for the first time, 2.5 hours for the second time, filter, merge filtrate, add crospovidone 20g (200 mesh sieves), mix homogeneously, reduce Concentrate under pressure until the relative density measured by heat is 1.10, and dry in vacuum to obtain a loose and non-sticky dry paste.

Embodiment 3

[0027] Get 600g Magnolia officinalis and use 4800ml 80% ethanol, reflux extraction 2 times, each time 2.5 hours, filter, combine filtrate, add pregelatinized starch 30g, starch 10g, mix well, reduce pressure and concentrate until the relative density of thermal measurement is 1.2- 1.25, vacuum-dried to obtain a loose and non-sticky dry paste.

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PUM

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Abstract

The invention relates to a method for changing viscosity of a Magnolia extractive, which comprises the following steps: reflowing and extracting a Magnolia medicinal material by 50 to 80 percent ethanol with amount of 5 to 10 times of that of the Magnolia medicinal material; combining filtrate to obtain an extractum-shaped extractive; or reflowing and extracting the Magnolia medicinal material by water with amount of 8 to 12 times of that of the Magnolia medicinal material, condensing and performing alcohol precipitation of the obtained product to remove sediment and obtain a liquid extractive; adding the liquid extractive to a sorbent, and decompressing and condensing to obtain an extractum; or adding a sorbent in the extractum-shaped extractive, fully and evenly mixing the mixture and performing vacuum drying on the mixture to prepare the Magnolia extractive. In the method of the invention, a medicinal auxiliary material is adopted as the sorbent which is used as a carrier of an active ingredient, and adsorbs the active ingredients and viscous substances of the Magnolia extractive inside auxiliary material particles so as to change the physical property of large external viscosity and ensure the smooth implementation of a preparation molding process.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a method for extracting magnolia bark Chinese medicinal material, more specifically, a method capable of changing the self-viscosity of the magnolia bark extract and the application of the obtained magnolia bark extract in the preparation process. technical background [0002] The research on solid preparations of traditional Chinese medicine has been committed to the research and development of solid preparations of traditional Chinese medicine and the research of key technologies for industrialization. Magnolia officinalis Rehd. et Wils. is a unique and precious traditional Chinese medicinal material in my country, mainly distributed in western Hubei, southwestern Sichuan, southern Shaanxi and southern Gansu; Magnolia officinalis Rehd. etWils) or Magnolia officinalis Rehd.et Wils.Var.biloba Rehd.et wils dry bark, root bark (called root bark), or b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61K47/38A61K47/32A61K47/36A61K47/40A61K47/04A61K47/02A61P1/14A61P1/08A61P11/06A61P11/10A61P11/14A61P1/12A61K125/00A61K129/00
Inventor 邓晓尧李勇王学元
Owner TIANJIN CENT PHARM CO LTD
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