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RNA interference sequence of glucagon receptor gene

A technology of RNA interference and glucagon, which is applied in the field of RNA interference sequence, to achieve the effect of improving glucose utilization ability and reducing blood sugar concentration

Inactive Publication Date: 2009-11-25
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After searching the literature of the prior art, it is found that there is no relevant report on the RNA interference sequence of the glucagon receptor gene

Method used

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  • RNA interference sequence of glucagon receptor gene
  • RNA interference sequence of glucagon receptor gene

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Embodiment

[0015] Reagent: Alloxan monohydrate (HPLC pure reagent, purchased from Sigma, USA, product number A7413);

[0016] Glucose determination kit - glucose oxidase-peroxidase method (purchased from Shanghai Rongsheng Biotechnology Co., Ltd., product number 361510, batch number 20030101);

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Abstract

The invention, which belongs to the field of gene technique, relates to a RNA interference sequence of glucagon receptor gene, the first kind of RNA interference sequence is a double-chain RNA molecule, and the sense strand of the RNA molecule has a sequence shown by SEQ ID NO:1, and the antisense strand has a sequence shown by SEQ ID NO:2; the second kind of RNA interference sequence is a double-chain RNA molecule, and the sense strand of the RNA molecule has a sequence shown by SEQ ID NO:3, and the antisense strand has a sequence shown by SEQ ID NO:4; the third kind of RNA interference sequence is a double-chain RNA molecule, and the sense strand of the RNA molecule has a sequence shown by SEQ ID NO:5, and the antisense strand has a sequence shown by SEQ ID NO:6. The interference RNA sequence provided by the invention can effectively reduce blood sugar concentration of diabetes model small mouse, thereby improving ability of small mouse for using glucose.

Description

technical field [0001] The invention relates to an RNA interference sequence in the field of gene technology, in particular to an RNA interference sequence of a glucagon receptor (GCGR) gene. Background technique [0002] RNA interference (RNA interference, RNAi) is a phenomenon that inhibits the expression of specific genes in organisms. It means that when there is a double-stranded RNA homologous to the endogenous mRNA coding region in the cell, the mRNA is degraded, resulting in gene expression. The phenomenon of silencing, which occurs at the post-transcriptional level, is also known as post-transcriptional gene silencing. RNA interference is achieved through a relatively stable intermediate medium. Studies on plants have proved that double-stranded RNA complexes are first degraded into small RNA molecules of about 35 nt, and then they bind to mRNA through sequence complementarity, resulting in mRNA degradation. Studies on Drosophila have proved that small RNA molecule...

Claims

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Application Information

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IPC IPC(8): C12N15/11A61P3/10C12N15/113
Inventor 徐宇虹周洁彭金良
Owner SHANGHAI JIAO TONG UNIV
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