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Stable peroxide containing personal care compositions

A technology of peroxide and composition, which is applied in oral care, cosmetic preparations, pharmaceutical formulations, etc., and can solve problems such as insufficient stability

Inactive Publication Date: 2009-11-11
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Formulating products that contain peroxides presents significant challenges, primarily because many traditional organic compound components, including actives, fragrances, colorants, and other aesthetic ingredients, are highly reactive in the presence of peroxides and peroxide-derived reactive species. Not stable enough especially in the presence of free radicals

Method used

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  • Stable peroxide containing personal care compositions
  • Stable peroxide containing personal care compositions
  • Stable peroxide containing personal care compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0172] Embodiment 1: Mouthwash composition

[0173] Mouthwash compositions IA-ID were prepared by mixing the following ingredients shown in percentages by weight of the composition. Formulation IA included Glass H as a free radical scavenger. Formulations IB to ID were treated with a polymer-supported chelating agent to reduce trace metals that could lead to free radical formation. Formulation IC contained stannous chloride as a free radical scavenger; Formulation ID contained stannous chloride and propyl gallate as a free radical scavenger.

[0174] Element

Embodiment II

[0175] Example II: Stability of Compositions

[0176] The stability of the compositions of the present invention was assessed by measuring any changes in the levels of peroxide, active ingredient (cepyridinium chloride) and flavor ingredient under storage conditions of 40°C and 75% relative humidity.

[0177] Use of water-compatible PeroXOquant TM Quantitative peroxide detection assay for the determination of hydrogen peroxide based on the oxidation of ferrous iron to ferric ions in the presence of xylenol orange to detect peroxides. Peroxide first reacts with sorbitol, converting it into peroxyl radicals, which in turn initiate Fe 2+ Oxidized to Fe 3+ . Fe 3+ Complexes with xylenol orange dye to give a purple product. This complex was measured using a microplate spectrophotometer at a wavelength of 595 nm to determine the hydrogen peroxide in the sample. This method has a margin of error of up to about 10%.

[0178] The effect of metal removal

[0179] Two batches...

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PUM

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Abstract

The present invention relates to stable personal care composition, including oral care compositions containing a peroxide source. The compositions are stabilized by eliminating or minimizing the presence in the composition of metals having radical forming potential with the peroxide. Preferably, the metals that are eliminated or reduced are cobalt, copper, palladium, nickel and iron. The compositions are further stabilized by the addition of agents having scavenging or quenching activity for free radicals. Reducing free radical activity in the product matrix prevents radical- mediated loss and degradation of peroxide and other ingredients, in particular organic compounds added as active or aesthetic agents, including flavors, perfumes, colorants and thickeners. Provided are peroxide containing oral care products with enhanced consumer appeal in terms of taste, mouthfeel and appearance, thereby encouraging compliance and regular use. Such attributes are important since use of these products may involve fairly long residence time in the mouth for efficacy.

Description

field of invention [0001] The present invention relates to stable personal care compositions, including oral care compositions comprising a source of peroxide. The compositions are stabilized against loss and degradation of peroxides and other composition ingredients, particularly organic compounds added as actives or aesthetics, including flavors, fragrances, colorants and thickeners. Peroxide sources are included in personal care compositions such as dentifrices and mouthwashes for bleaching / whitening and antimicrobial benefits. However, formulating compositions comprising stable peroxides is a formidable challenge for a number of reasons. These challenges are primarily due to the reactivity of peroxides, and the instability or susceptibility to degradation of many composition ingredients in the presence of peroxides or reactive species derived from peroxides, such as free radicals. Included in the present invention are oral care products comprising peroxides which are sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/22A61Q11/00
CPCA61Q11/00A61K8/19A61K8/22
Inventor 尼兰詹·拉姆吉
Owner PROCTER & GAMBLE CO
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