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Medicinal material composition used for lowering lipid and protecting liver auxiliarily

A lipid-lowering, liver-protecting and auxiliary technology, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve problems that have not attracted enough attention, and achieve the effect of delaying drunkenness

Active Publication Date: 2009-11-11
徐琳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, alcoholic liver disease has received attention in foreign countries for a long time, and Japan has started research on the treatment and health care of alcoholic liver disease since the 1980s, while my country has not yet attracted enough attention

Method used

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  • Medicinal material composition used for lowering lipid and protecting liver auxiliarily
  • Medicinal material composition used for lowering lipid and protecting liver auxiliarily
  • Medicinal material composition used for lowering lipid and protecting liver auxiliarily

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1 tablet preparation

[0073] Prepare medicinal material composition tablet according to following steps:

[0074] 1) Put 187.5g papaya, 187.5g tangerine peel, 187.5g atractylodes atractylodes, 625g salvia miltiorrhiza, 312.5g sealwort and 625g hawthorn in a container, first use 10 times the amount of 70% (v / v) ethanol to reflux for 2 hours, and then use Eight times the amount of 70% (v / v) ethanol was refluxed for 1.5 hours to obtain the ethanol extract and the solid residue of medicinal materials;

[0075] 2) Put 375g of turtle shell, 187.5g of Hovenia dulcis, 187.5g of Alisma, 375g of lotus leaf and the solid residue of medicinal materials obtained in step 1 into a container, and then decoct with 8 times the amount of water for 2 hours, and then use Decoct with 8 times the amount of water for 3 hours, and finally stand and filter to obtain the water extract;

[0076] 3) after the ethanol extract obtained in step 1 and the water extract obtained in step 2 ...

Embodiment 2

[0078] Embodiment 2 Auxiliary hypolipidemic animal experiment

[0079] Wistar male rats were divided into a control group and three administration groups with different doses, totally four groups, with 12 animals in each group. Animals in the four groups were given high-fat feed with the same composition and the same amount. The animals in the three administration groups were given the tablet prepared in Example 1, and the doses per kilogram of body weight were: 0.27g, 0.53g and 1.6g, respectively. Oral gavage was performed once a day, and serum total cholesterol and triglyceride were measured after continuous gavage for 32 days. The control group was given the same volume of water every day.

[0080] Composition of high-fat feed: 78.8% basic feed (Institute of Experimental Animals, Chinese Academy of Medical Sciences), 1% cholesterol, 10% egg yolk powder, 10% lard and 0.2% bile salt.

[0081] Determination of serum total cholesterol:

[0082] After the animals in the four g...

Embodiment 3

[0092] Example 3 Auxiliary Chemical Hepatic Injury Protection

[0093] Kunming male mice were divided into a model control group, a blank control group and three administration groups with different doses, a total of four groups with 12 animals in each group. Animals in the five groups were given high-fat feed with the same composition and the same amount. The animals in the three groups of administration groups were given the tablet prepared in Example 1, and the doses per kilogram of body weight were: 0.53 g, 1.07 g and 3.20 g, respectively. Oral gavage once a day, after continuous gavage for 35 days, alanine aminotransferase and liver tissue section pathological analysis were measured. The control group was given the same volume of water every day.

[0094] After the 33rd day of continuous administration, the animals in each group were fasted for 16 hours, and the model control group and each administration group were intragastrically administered 1% carbon tetrachloride ...

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Abstract

The invention discloses a medicinal material composition used for lowering lipid and protecting liver auxiliarily, which comprises the following medicinal materials: hovenia dulcis thumb, alisma orientale, turtle shell, pawpaw, dried old orange peel, rhizoma atractylodis, salvia miltiorrhiza, rhizoma polygonati, hawthorn and lotus leaf. The composition has the efficacies of combining tonification and purgation, paying attention to both superficies and hypostasis, eliminating dampness and invigorating blood circulation synchronously, regulating the flow of qi, resolving lump, supplementing qi and nourishing yin, and can remove turbid damp and alcoholic toxicant, regulate mechanism of qi to be smooth, dispel blood stasis and dredge collaterals, and remove pathogenic factors for the reinforcement of vital energy. Verified by zoopery, the medicinal material composition has assistant lipid-lowering function and assistant protection function against chemical liver injury. The medicinal material composition can play the role of assistant protection on the liver when neutralizing the effect of alcoholic drinks, sobering up, delaying intoxication or relieving intoxication symptoms.

Description

technical field [0001] The invention relates to a composition of medicinal materials, in particular to a composition composed of medicinal materials such as hawthorn, salvia miltiorrhiza, sealwort, lotus leaf, Alisma and turtle shell, and its use in the adjuvant treatment of hypolipidemic and chemical liver injury Applications. Background technique [0002] With the rapid improvement of people's living standards in our country, the number of patients with dyslipidemia among adults in our country has increased rapidly. At present, one-third of adults in my country have high blood lipids. At the same time, the consumption of alcohol has increased sharply, and the incidence of alcoholic liver disease has also increased significantly. In Western countries, Japan, Korea and other countries where alcoholism is serious, alcoholic liver cirrhosis accounts for 50-70% of patients with liver cirrhosis. Therefore, alcoholic liver disease has been paid attention to in foreign countrie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P3/06A61P1/16A61P39/00A61K35/56A61K35/586
Inventor 徐琳
Owner 徐琳
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