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Iron (III)-carbohydrate based phosphate adsorbent

A phosphate adsorbent, carbohydrate technology, applied in the direction of iron compounds, iron organic compounds, iron group organic compounds without C-metal bonds, etc., can solve the problems of low adsorption capacity of phosphate adsorbents and low patient compliance.

Active Publication Date: 2009-10-21
ELANCO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This suggests low patient compliance with existing phosphate sorbents
[0013] Due to the high levels of phosphate contained in the diet and the relatively low adsorption capacity of phosphate adsorbents available or described in the prior art, it is necessary to apply high doses of such adsorbents to effectively control phosphate blood concentration

Method used

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  • Iron (III)-carbohydrate based phosphate adsorbent
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  • Iron (III)-carbohydrate based phosphate adsorbent

Examples

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preparation example Construction

[0046] The preparation method of gamma-iron (III)

[0047] It was not expected that gamma-iron(III) oxyhydroxides could be obtained selectively directly from iron(III) sources such as iron(III chloride) without the use of iron(II) and subsequent oxidation steps, and gamma-iron(III) A mixture of iron(III) oxyhydroxides and ferrihydrite.

[0048] The present invention also includes a novel process for the preparation of gamma-iron(III) oxyhydroxides comprising the steps of: bringing an aqueous solution of an iron(III) salt with an aqueous base solution between pH 6-10, optionally in the presence of starch reaction. Starch can be added after the reaction of step a), that is, after the iron salt and alkali are completely mixed.

[0049] If not present in step a), starch can be added in another step (step b), for example after the iron salt and alkali have been thoroughly mixed. In another embodiment, starch is added in step a) and more starch is added in step b).

[0050] In...

Embodiment 1

[0239] Example 1 : Preparation of Iron(III)-Based Phosphate Adsorbents

[0240] To a mixture of 41 kg potato starch, 118 kg sodium carbonate and 480 kg water was added a solution of 148 kg iron(III) chloride hexahydrate in 588 kg water within 30 minutes at a temperature of 20-35°C. The resulting brown suspension was stirred at 25°C for at least 60 minutes, then filtered and washed 3 times with 968 kg of water, each time using a decanter centrifuge. Then 160 kg of water, 41 kg of sucrose and 129 kg of ethanol were added and the mixture was stirred for at least 60 minutes. 172 kg of a russet powdery final product was isolated by spray drying using NIRO SD42 under appropriate spray drying parameters or at an atomization pressure of 1.2 bar, an output temperature of 65° C. and an input temperature of 140° C.

[0241] The product can be filled directly into sachets or stick packs without any other treatment.

Embodiment 2

[0242] Example 2 : Preparation of Iron(III)-Based Phosphate Adsorbents

[0243] A solution of 21.1 g of sodium carbonate in 105 g of water (solution A) and a solution of 26.5 g of iron(III) chloride hexahydrate in 55 g of water (solution B) were prepared. Add solutions A (4.2 g / min) and B (2.7 g / min) to a solution of 7.36 g of potato starch in 40 g of water over 30 minutes: Mix solutions A and B continuously and then add to the potato starch suspension . The resulting russet suspension was stirred at 25° C. for at least 1 hour, filtered and washed 3 times with 173.6 g of water each time. To the obtained russet solid were added 14.6 g of water, 7.36 g of sucrose and 24.2 g of ethanol, and the mixture was stirred for 60 minutes. Fluidized spray drying with appropriate FSD conditions yielded 18.4 g of the final product.

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Abstract

The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphatemia.

Description

[0001] The present invention relates to novel iron-containing phosphate adsorbents, processes for their preparation, their use and pharmaceutical compositions containing them. Background of the invention [0002] Phosphorus is critical for bone mineralization, cellular structure, genetic code and energy metabolism. It exists in many organic and inorganic forms. Phosphorus is present in almost all foods, and gastrointestinal absorption in dietary form is very efficient. Phosphorus homeostasis is usually maintained by several mechanisms (renal excretion, cellular release, hormone regulation, etc.). Hyperphosphatemia occurs when phosphorus loading (from gastrointestinal absorption, exogenous administration, or cellular release) exceeds renal excretion and tissue absorption. [0003] Hyperphosphatemia is associated with significant increases in mortality and morbidity and can induce serious complications such as hypocalcemia, decreased vitamin D production, and migratory calcifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/00A61K33/26C07F15/02B01J20/06
CPCC07F15/025B01J20/0229B01J20/06A61K33/26B01J20/24
Inventor M·安布尔C·热西耶-比亚尔C·哈特曼D·考夫曼E·屈斯特斯U·迈耶A·迈尔N·塞卡特
Owner ELANCO
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