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Syringin for injection, preparation method and application thereof

A technology for syringin and injection, which is applied in the field of syringin powder injection and its preparation, and can solve the problems of easy oxidation, decreased content, poor stability of preparations, etc.

Inactive Publication Date: 2009-10-14
苑立超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Syringin can be dissolved in hot water, but its preparation has poor stability, is easily oxidized, and is sensitive to light and heat, resulting in a decrease in content and an increase in impurities. The guarantee of its stability is a technical difficulty

Method used

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  • Syringin for injection, preparation method and application thereof
  • Syringin for injection, preparation method and application thereof
  • Syringin for injection, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation process of syringin for injection is as follows: Dissolve 1.0 g of sodium bisulfite in 1200 ml of water for injection, add 500 mg of disodium edetate and 2.0 g of vitamin C, dissolve and mix well, heat to 50°C, and then Dissolve 50g of syringin in the above solution, add 100g of mannitol, and add an appropriate amount of dilute hydrochloric acid solution to adjust the pH to 3.5, add 0.01% activated carbon for injection and stir at 50°C for 20 minutes, then filter, then make up water for injection to 1500ml and pass through 0.22 The film of μm is made into 1000 tubes, filled in vials and freeze-dried according to the freeze-drying process.

[0043] The syringin for injection prepared by the above method, molecular formula: C 17 h 24 o 9 , molecular weight: 372.36, its structural formula is:

[0044]

Embodiment 2

[0046] The difference from the syringin for injection described in Example 1 is that 1.5 g of sodium bisulfite, 10 g of vitamin C, and 300 mg of disodium edetate are dissolved in 1500 ml of water for injection, heated to 55° C., and then Dissolve 100g of syringin in the above solution, then add 200g of dextran, adjust the pH to 4.0 with an appropriate amount of dilute phosphoric acid, add 0.05% activated carbon for injection and stir at 50°C for 20 minutes, filter the water for injection to a total volume of 2000ml, and pass through a 0.22μm membrane. Made 1000 pieces. Fill in vials and freeze-dry according to the freeze-drying process.

Embodiment 3

[0048] The difference from the syringin for injection described in Example 1 is that 500 mg of edetate calcium sodium and 20 g of D-isoascorbic acid are dissolved in 2000 ml of water for injection, heated to 60 ° C, and then 150 g of syringin is dissolved in Add 200g of lactose to the above solution, adjust the pH to 3.5 with L-cysteine ​​hydrochloride solution and dilute tartaric acid solution, add 0.2% activated carbon for injection and stir at 50°C for 20 minutes, filter and supplement the water for injection to a full amount of 2500ml, and Pass through a 0.22 μm membrane, make 1000 tubes, fill in vials and freeze-dry according to the freeze-drying process.

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Abstract

The invention relates to a syringin for injection, a preparation method and the application thereof. The invention can provide an injection that is clinically and safely used and has the pharmacological actions of resisting fatigue, tranquilizing and allaying excitement, expanding blood vessel, reducing blood viscosity, stanching, and the like. The injection contains syringin, pharmacology-permissible pH regulating substance, a stabilizing agent and an excipient. 50-2800 mg dry substance in each injection contains 5-2000 mg of syringin, 0.04-0.8 g of excipient and 0.0001-0.1g of stabilizing agent. Of the above substance, the pH regulating substance has an adding amount for regulating the weight fraction pH value to 3.5-7.5. The product of the invention is used for preparing medicaments for resisting fatigue, tranquilizing and allaying excitement, expanding blood vessel, reducing blood viscosity, stanching, resisting dumps.

Description

Technical field: [0001] The invention relates to a syringin powder injection and a preparation method thereof, as well as the application of the substance in preparation of injections with pharmacological effects such as anti-fatigue, calming the nerves, dilating blood vessels, reducing blood viscosity, and stopping bleeding. Background technique: [0002] At present, the relevant injections containing syringin in the market are only traditional Chinese medicine compound preparations such as Acanthopanax injection, and there is no syringin injection for clinical use. Syringin is a water-soluble substance isolated and extracted from the bark of Syringa vulgarisL. in the family Oleaceae, and Acanthopanax and other plants. It is the main active ingredient in Chinese medicinal materials such as Acanthopanax. [0003] According to the current domestic extraction process, injections made from syringin raw materials have the characteristics of high purity, high pharmacological acti...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/00A61K31/7034A61P25/00A61P9/00
Inventor 苑立超
Owner 苑立超
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