Cyclic peptide compound in Hsisha sponge and application thereof
A cyclic peptide compound and application technology, applied in the field of medicine, can solve problems such as new cyclic peptide compounds with no anti-tumor activity, and achieve the effects of remarkable anti-tumor activity and simple preparation method
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[0014] Embodiment 1. Preparation of compounds of the present invention
[0015] Take 15 kg of dried and pulverized brown flat sponge, extract by cold soaking in 50 L of 95% ethanol for 8 times, each time for one week, combine the extracts, concentrate the extracts under reduced pressure to obtain extracts, and extract with 50% ethyl acetate aqueous solution, To obtain the total ethyl acetate extract, suspend the total ethyl acetate extract with 90% methanol, degrease with petroleum ether, add water to adjust the methanol concentration of the suspension to 60%, extract 3 times with dichloromethane, and concentrate Extract, get crude extract 55g;
[0016] 55 g of the above-mentioned crude extract was passed through a Sephadex LH-20 gel column, and the 2 Cl 2 -MeOH=1:1 elution, according to the thin layer chromatography detection results, collect the eluate containing cyclic peptide compounds, and then perform reverse phase silica gel column chromatography, use methanol with a ...
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