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Compound preparation for treating ophthalmic infection and inflammation

A technology for compound preparations and eye infections, which is applied in the direction of anti-inflammatory agents, drug combinations, and medical preparations containing active ingredients, etc., which can solve problems such as shortages, achieve convenient application, and improve the effect of treatment

Inactive Publication Date: 2009-09-02
WUHAN NUOAN PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, only erythromycin eye ointment is the only macrolide antibiotic used locally in ophthalmology in China, and the compound preparation composed of macrolide antibiotics and steroidal anti-inflammatory drugs is even more lacking.

Method used

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  • Compound preparation for treating ophthalmic infection and inflammation
  • Compound preparation for treating ophthalmic infection and inflammation
  • Compound preparation for treating ophthalmic infection and inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: Preparation of Azithromycin Dexamethasone Sodium Phosphate Eye Drops

[0033] prescription:

[0034] Azithromycin 1.0g

[0035] Dexamethasone Sodium Phosphate 0.1g

[0036] Hypromellose 2.0g

[0037] Citric acid 1.0g

[0038] Sodium chloride 0.147g

[0039] Disodium edetate 0.01g

[0040] Cetrimonium Bromide 0.005

[0041] Appropriate amount of sodium hydroxide

[0042] Add water for injection to 100ml

[0043]

[0044] Preparation method: Dissolve the prescribed amount of hypromellose and dexamethasone sodium phosphate in about 40% water for injection, and set aside; then dissolve the prescribed amount of citric acid with about 50% water for injection, then add azithromycin, Sodium chloride, edetate disodium, and cetrimonium bromide were stirred to dissolve, and the pH was adjusted to 6.0-6.5 with sodium hydroxide. Mix the two solutions together, add water for injection to the full amount, and stir evenly. In the middle inspection, use a 0.22...

Embodiment 2

[0045] Embodiment 2: Preparation of Azithromycin Prednisolone Sodium Phosphate Eye Drops

[0046] prescription:

[0047] Azithromycin 1.0g

[0048] Prednisolone Sodium Phosphate 1.0g

[0049] Hypromellose 2.0g

[0050] Citric acid 1.0g

[0051] Sodium chloride 0.147g

[0052] Disodium edetate 0.01g

[0053] Cetrimonium Bromide 0.005

[0054] Appropriate amount of sodium hydroxide

[0055] Add water for injection to 100ml

[0056]

[0057]Preparation method: Dissolve the prescribed amount of hypromellose and prednisolone sodium phosphate in about 40% water for injection, and set aside; then dissolve the prescribed amount of citric acid with about 50% water for injection, and then add azithromycin , sodium chloride, disodium edetate, and cetrimonium bromide, stir to dissolve, and adjust the pH to 6.0-6.5 with sodium hydroxide. Mix the two solutions together, add water for injection to the full amount, and stir evenly. In the middle inspection, use a 0.22um filter me...

Embodiment 3

[0058] Embodiment 3: Preparation of Azithromycin Dexamethasone Eye Drops

[0059] prescription:

[0060] Azithromycin 1.0g

[0061] Dexamethasone 0.1g

[0062] Hypromellose 2.0g

[0063] Citric acid 1.0g

[0064] Tween-80 0.8g

[0065] Sodium chloride 0.13g

[0066] Disodium edetate 0.01g

[0067] Cetrimonium Bromide 0.005g

[0068] Appropriate amount of sodium hydroxide

[0069] Add water for injection to 100ml

[0070]

[0071] Preparation method: Dissolve the prescribed amount of hypromellose, disodium edetate, cetrimonium bromide, and Tween-80 in about 40% water for injection, and then dissolve the prescription with about 50% water for injection Add a certain amount of citric acid, then add azithromycin, sodium chloride, and stir to dissolve, adjust the pH to 6.0-6.5 with sodium hydroxide, mix the two solutions together, add water for injection to the full amount, and stir evenly. After filtering and sterilizing with a 0.22um filter membrane, add dry-heat ster...

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PUM

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Abstract

The invention relates to a compound preparation for treating ophthalmic infection and inflammation, which is characterized by comprising a large-ring lactone antimicrobial drug and steroidal anti-inflammatory drug and being used for treating ophthalmic infection and inflammation. The large-ring lactone antimicrobial drug comprises azithromycin, clarithromycin and roxithromycin and the like; and the steroidal anti-inflammatory drug comprises dexamethasone, dexamethasone acetate, dexamethasone sodium ascorbyl phosphate, prednisolone acetate, prednisolone, prednisolone sodium ascorbyl phosphate, betamethasone and betamethasone sodium ascorbyl phosphate and the like. The invention is a compound preparation which is superior to single drug-using and has good treatment effect.

Description

Technical field: [0001] The invention relates to a locally applied medicine, in particular to a chemical medicine compound preparation for treating eye infection and inflammation. technical background: [0002] Ocular infection and inflammation are common diseases in ophthalmology. Chloramphenicol, aminoglycosides, fluoroquinolones, and steroidal anti-inflammatory drugs are commonly used clinically. In terms of compound preparations, there are tobramycin / dexamethasone eye drops produced by Alcon Company of the United States, the trade name is TOBRADEX; Su / fluorometholone eye drops, the trade name is Yituofen. Alcon has applied for a patent for a topical suspension composed of fluoroquinolone antibacterials and dexamethasone in China. See Chinese patent CN1158994C, O·N·Singer, H·G·Bergout. Local suspension preparation containing ciprofloxacin and dexamethasone. Compound preparations composed of aminoglycoside antibacterial drugs and steroidal anti-inflammatory drugs such a...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/7048A61P27/02A61P29/00A61P31/04A61K31/573
Inventor 肖学成卢山
Owner WUHAN NUOAN PHARMACY
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