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Quality control method of compound Chinese lobelia oral preparation and use thereof

A quality control method and oral preparation technology, applied in the field of traditional Chinese medicine, can solve problems such as inconvenient use of injections, restrictions on popularization and use, and adverse reactions of patients, and achieve the effects of improving quality control methods, ensuring safety, and controlling quality

Inactive Publication Date: 2009-07-15
FUREN PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the inconvenient use of injections and the tendency to cause adverse reactions in patients, the promotion and use of this variety is limited.

Method used

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  • Quality control method of compound Chinese lobelia oral preparation and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Get the compound lobelia oral liquid whose batch number is 070507 produced by Furen Medical Technology Development Co., Ltd.

[0029] (1), identifying the compound lobelia oral liquid containing lobelia:

[0030] Take 10ml of this product, add 1ml of dilute hydrochloric acid, shake and extract twice with petroleum ether (60~90℃), 10ml each time, discard the petroleum ether solution, adjust the pH value of the aqueous solution to 9~10 with ammonia test solution, and use chloroform Shake and extract twice, 10ml each time, combine the extracts, evaporate to dryness, add 1ml of chloroform to the residue to dissolve, and use it as the test solution. Take another 2 g of lobelia reference medicinal material, add 100 ml of water, boil, keep boiling slightly for 30 minutes, filter, concentrate the filtrate to 10 ml, adjust the pH value to 9~10 with ammonia test solution, and prepare the reference medicinal material solution in the same way. According to the test of thin-layer c...

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Abstract

The invention relates to a mass control method of a traditional Chinese medicine compound Chinese Lobelia oral formulation and the application thereof. Based on the mass control standard of compound Chinese Lobelia injecta, the content of coumaric acid in Chinese Lobelia, herba scutellariae barbatae and herba oldenlandiae is additionally measured to synthetically control the prescription. The invention improves the mass control method of compound Chinese Lobelia oral formulation, more effectively controls the quality of the compound Chinese Lobelia oral formulation, and ensures the safety of people taking the compound Chinese Lobelia oral formulation.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a quality control method and application of traditional Chinese medicine compound lobelia oral preparations. Background technique [0002] Compound lobelia injection is a modern traditional Chinese medicine preparation approved by the State Food and Drug Administration for clinical application. Compound lobelia injection is a sterilized aqueous solution extracted from traditional Chinese medicine lobelia, barbata, and hedyotis diffusa. It has the effects of clearing heat and detoxifying, reducing swelling and relieving pain. Treatment of inflammation etc. Although the compound lobelia injection has been on the market for many years, it has a positive clinical effect. However, because the injection is inconvenient to use and easily causes adverse reactions in patients, the promotion and use of this variety is limited. Therefore, we changed the route of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P11/04A61P15/14A61P17/02G01N30/02G01N30/90
Inventor 朱成功
Owner FUREN PHARMA GROUP
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