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Terpyridyl complex two-photon material with cell development and preparation

A technology for terpyridine and cell development, which is applied to zinc organic compounds, preparations for in vivo tests, pharmaceutical formulations, etc., can solve the problems of not obtaining sulfur atom end groups and the like, and achieves low cost, easy availability of raw materials, and simple synthesis steps. Effect

Inactive Publication Date: 2011-05-04
ANHUI UNIVERSITY
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Problems solved by technology

However, due to the high electron-richness of sulfur, there have been no complexes coordinated by the end group of the sulfur atom. Most of the reported polynuclear complexes and clusters are sulfur atoms bridging two or more metal centers.

Method used

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  • Terpyridyl complex two-photon material with cell development and preparation
  • Terpyridyl complex two-photon material with cell development and preparation
  • Terpyridyl complex two-photon material with cell development and preparation

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Embodiment Construction

[0040] 1. Preparation of terpyridine derivatives

[0041] The synthesis of terpyridine derivatives is based on the Wittg reaction between phosphonium salts and aldehydes.

[0042] Firstly, according to the literature (Bull.Chem.Soc.Jpn.2007, 80, 986-993), the phosphine salt of terpyridyl group is prepared, and the synthetic route is as follows:

[0043]

[0044] Then, according to the Wittg reaction, the phosphonium salt, R-CHO and potassium tert-butoxide were thoroughly ground in a mortar until viscous, and the 2 Cl 2 The target product was obtained by dissolving, washing with water, drying, filtering, concentrating and column separation.

[0045] Taking R-CHO as N-hexylcarbazole formaldehyde as an example, the synthetic route is as follows:

[0046]

[0047] 2. Synthesis of the target product

[0048] Take the terpyridine derivative (marked as L) when R is N-hexylcarbazole as the auxiliary ligand as an example. at 20cm 3 19.4mg (0.2mmol) of ZnS nanocrystals, 115....

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Abstract

The invention disclose a two photon absorption material capable of imaging alive cells, which is a terpyridine derivative Zn(II)S2 complex shown by the following structural formula. The complex is a two photon absorption material having a property of two-photon fluorescence imaging of alive tissue cells, has the characteristics of large absorption area, low excitation energy, large wavelength, high penetrability, less light injuries, non-toxicity and the like and is suitable to be used for detecting alive cells.

Description

1. Technical field: [0001] The invention relates to a two-photon absorption material and a preparation method thereof, in particular to a two-photon absorption material with the function of developing living tissue cells and a synthesis method thereof. 2. Background technology [0002] In recent years, with the discovery of two-photon absorbing materials, two-photon fluorescence technology has made a major breakthrough in its application. Since the two-photon technology uses long-wavelength excitation (near-infrared), it has the characteristics of low excitation energy, long wavelength, strong penetration, and small photodamage. It has attractive application prospects in medical diagnosis and fluorescence microscopy imaging. In 2004, O'Halloran (J.Am.Chem.Soc., 2004, 126, 712-713) reported the use of Zn(II) ion-centered complex two-photon fluorescence microscopy in the detection of living tissue cells The application of this method has successfully solved the disadvantage o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F3/06C07D213/89A61K49/00
Inventor 田玉鹏高远浩吴杰颖张胜义周虹屏杨家祥金葆康李胜利薛照明马文张骞
Owner ANHUI UNIVERSITY
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