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Hydroxypropyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material

A technology for oxidizing sodium alginate and hydroxypropyl chitosan, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problem of less hydroxypropyl chitosan hydrogel, and achieve excellent bacteriostatic properties and water content. High and low cost effect

Active Publication Date: 2009-06-24
日照武汉理工大生物医药暨新材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are few reports on hydroxypropyl chitosan hydrogel at home and abroad, mainly focusing on the preparation of hydrogels with formaldehyde and glutaraldehyde as cross-linking agents. glue research
However, there is no report on the self-crosslinking antibacterial hydrogel material of hydroxypropyl chitosan / oxidized sodium alginate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of hydroxypropyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material

[0029] By weight, 4% of hydroxypropyl chitosan, 4% of oxidized sodium alginate and 91.9% of distilled water were prepared into an aqueous solution of the two, then blended, added 0.1% of nano-silver, and waited for self-crossing at 10-50°C The hydroxypropyl chitosan / oxidized sodium alginate self-crosslinked antibacterial hydrogel material was obtained.

Embodiment 2

[0030] Example 2: Preparation of hydroxypropyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material

[0031] By weight, 7% of hydroxypropyl chitosan, 6% of oxidized sodium alginate and 86.95% of distilled water were prepared into an aqueous solution of the two, then blended, added 0.05% of nano-silver, and waited for self-crossing at 10-50°C The hydroxypropyl chitosan / oxidized sodium alginate self-crosslinked antibacterial hydrogel material was obtained.

Embodiment 3

[0032] Example 3: Preparation of hydroxypropyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material

[0033] By weight, 15% of hydroxypropyl chitosan, 14% of oxidized sodium alginate and 82.9% of distilled water were prepared into an aqueous solution of the two, then blended, added 0.5% of nano-silver, and waited for self-crossing at 10-50°C The hydroxypropyl chitosan / oxidized sodium alginate self-crosslinked antibacterial hydrogel material was obtained.

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PUM

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Abstract

The invention discloses a self-crosslinking antibacterial hydrogel material containing hydroxypropyl chitosan / oxidized sodium alginate. The material is made from the following components by mass percent: 1-25% of hydroxypropyl chitosan, 1-30% of oxidized sodium alginate, 0.01-0.5% of nano-silver and distilled water. The material is prepared by the following steps: preparing the hydroxypropyl chitosan by a hydroxypropylation reaction of chitosan at the temperature of 10-90 DEG C; preparing the oxidized sodium alginate by an oxidation reaction of sodium alginate at the temperature of 10-45 DEG C; respectively preparing aqueous solution of the hydroxypropyl chitosan and aqueous solution of the oxidized sodium alginate; adding the nano-silver solution and blending at certain ratio; allowing self-crosslinking of the components at the temperature of 10-50 DEG C to produce the antibacterial hydrogel material. The antibacterial hydrogel material has the advantages of low cost, environmental protection, simple process and the like; as the hydroxypropyl chitosan has good biocompatibility, the oxidized sodium alginate is nontoxic to human body, and the nano-silver has excellent antibacterial property, the obtained material can be applied to wound dressing, hemostatic materials and the like.

Description

technical field [0001] The invention relates to the field of polymer material science, in particular to a hydroxypropyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material and a preparation method thereof. Background technique [0002] Hydroxypropyl chitosan is the C in the chitosan molecule 6 Another water-soluble derivative obtained by introducing a hydroxypropyl group into a hydroxyl group through an etherification reaction, the introduction of a hydroxypropyl group improves the water solubility of chitosan. Hydroxypropyl chitosan is often made into drug sustained-release materials. At the same time, hydroxypropyl chitosan has good film-forming properties, good biocompatibility, and is non-toxic to organisms, so it is more and more used in the field of medicine. The oxidized sodium alginate obtained by oxidizing sodium alginate with sodium periodate has a dialdehyde structure, which can replace the commonly used formaldehyde, glutaraldehy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08L5/04C08K3/08C08J3/24A61L15/28A61L15/18
Inventor 樊李红吁磊郑化周月潘晓然
Owner 日照武汉理工大生物医药暨新材料研究院
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