Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of cinnamyl-(6'-O-alpha-L- arabopyranose)- O-beta-D-glucopyranoside in preparing antidepressant medicine

A technology of arabinopyranoside and glucopyranoside, which is applied in the application field of preparing antidepressant drugs, can solve the problem that the antidepressant effect of monomer rosavin has not been reported and the like

Inactive Publication Date: 2012-03-21
上海嘉达信息科技有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] At present, the antidepressant effect of monomer rosavin in animal experiments has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of cinnamyl-(6'-O-alpha-L- arabopyranose)- O-beta-D-glucopyranoside in preparing antidepressant medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Preparation of rosavin ordinary capsules

[0138] Prescription: rosavin 40mg

[0139] Lactose 155mg

[0140] Carboxymethyl Starch Sodium 5mg

[0141] 5% povidone (K30) in 70% ethanol solution

[0142] Take rosavin, lactose, and sodium carboxymethyl starch through a 80-mesh sieve and mix evenly, add 5% povidone K30 in 70% ethanol solution to make a soft material, pass through a 40-mesh sieve to granulate. 50-60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.

Embodiment 2

[0144] Preparation of rosavin ordinary capsules

[0145] Prescription: rosavin 40mg

[0146] Microcrystalline Cellulose 155mg

[0147] Crospovidone 5mg

[0148] 5% povidone (K30) in 70% ethanol solution

[0149] Take rosavin, microcrystalline cellulose, and cross-linked povidone through a 80-mesh sieve and mix evenly, add an appropriate amount of 5% povidone K30 in 70% ethanol solution to make a soft material, and pass through a 40-mesh sieve to granulate. 50-60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.

Embodiment 3

[0151] Preparation of rosavin ordinary capsules

[0152] Prescription: rosavin 40mg

[0153] Povidone (K30) 160mg

[0154] Proper amount of ethanol

[0155] Magnesium Stearate 1mg

[0156] Get rosavin and povidone and add appropriate amount of ethanol to heat and dissolve, put the rotary evaporator to remove ethanol, cool, pulverize, pass through a 40 mesh sieve, add the prescribed amount of magnesium stearate, and mix well. Fill No. 1 capsules according to the prescribed amount, each containing rosavin40mg.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to applications of a compound cinnamyl-(6'-O-alpha-L-arabopyranose)-O-beta-D-glucopyranoside in pharmaceutical field. The compound can effectively resist blepharoptosis caused by reserpine or akinesia, resist small mouse thrill caused by L-5-HT, resist small mouse tail suspension or acquired desperation depression by a forced swinging method, strengthen L-dopa behavioural effect, and has no exciting or inhibiting effect to nerve centres. The action mechanism thereof may be related to breaking reuptake of NA, DA transmittances so as to increase concentration of the two transmittances in synaptic spaces. The compound has no toxic reactions in acute toxicity experiences on mice so that the compound with experience dosage has relatively high security and good anti-depression effect and can be used to treat depression.

Description

technical field [0001] The present invention relates to the use of chemical substances in the field of medicine. More specifically the application of the compound cinnamyl-(6'-O-α-L-arabinopyranose)-O-β-D-glucopyranoside (rosavin) in the preparation of antidepressant drugs Background technique [0002] Compound cinnamyl-(6'-O-α-L-arabinose)-O-β-D-glucopyranoside (rosavin), its structural formula is: [0003] [0004] Molecular formula: C 20 h 28 o 10 ; [0005] Molecular weight: 428.44 [0006] Appearance: white powder; [0007] CAS: 84954-92-7: [0008] Melting point: 171-173°C (ethanol); [0009] Optical rotation: -56.5° (chloroform / methanol 1:1); UVλ max 252nm belongs to the phenylpropanoid glycosides, originally in the Crassulaceae plant Rhodiola rosea. [0010] In 1983, G.G.Zapesochnaya and V.A.Kurkin first isolated three new cinnamyl alcohol glycoside compounds in the rhizome of Rhodiola rosea, and named them: rosin, rosavin, rosarin[]. The three compound...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7028A61P25/24
Inventor 惠永正吴伟泳杨翎
Owner 上海嘉达信息科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com