Magnesium isoglycyrrhizinate cream and preparation method and use thereof
A magnesium glycyrrhizinate cream and a technology of magnesium isoglycyrrhizinate are applied in the field of external preparations of magnesium isoglycyrrhizinate, which can solve the problems of dry and cracked skin and incompatibility, and achieve the effects of improving compliance and being convenient to use.
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Embodiment 1
[0074] Embodiment 1: water-soluble base type ointment
[0075] Prescription (200g):
[0076] Magnesium Isoglycyrrhizinate 2g
[0077] Macrogol 4000 60g
[0078] Macrogol 400 90g
[0079] Water-soluble Azone 4g
[0080] Ethylparaben 0.2g
[0081] 10% ammonia water appropriate amount
[0082] Glycerin 10g
[0083] Distilled water up to 200g
[0084] Preparation method: 1. Dissolve magnesium isoglycyrrhizinate and an appropriate amount of 10% ammonia water in distilled water, dissolve ethylparaben in glycerin, mix well, add water-soluble azone, and stir well.
[0085] 2. Mix polyethylene glycol 4000 and polyethylene glycol 400, heat to about 70°C on a water bath, and stir well.
[0086] 3. Add (1) into (2), add water to 200g, stir until condensed, and you get it.
Embodiment 2
[0087] Embodiment 2: water-in-oil cream
[0088] Prescription (200g):
[0089] Magnesium Isoglycyrrhizinate 2g
[0090] Span 80 4g
[0091] Chlorocresol 0.4g
[0092] Beeswax 15g
[0093] Liquid paraffin 50g
[0094] White Vaseline 10g
[0095] Glyceryl monostearate 30g
[0096] 5% sodium hydroxide appropriate amount
[0097] Distilled water 88g
[0098] Preparation method: 1. Put beeswax, glyceryl monostearate, liquid paraffin, white vaseline and Span 80 into the oil phase, put it in an evaporating dish, and heat it to about 80°C on a water bath.
[0099] 2. Dissolve magnesium isoglycyrrhizinate plus an appropriate amount of 5% sodium hydroxide in distilled water, add chlorocresol, heat to about 80°C on a water bath, stir to dissolve, and form a water phase.
[0100] 3. Slowly add the water phase into the oil phase at about 80°C, and keep stirring on a water bath until it becomes a milky white semi-solid, and then stir at room temperature until it is nearly condensed. ...
Embodiment 3
[0101] Embodiment 3: Filled closed type magnesium isoglycyrrhizinate transdermal patch
[0102] The patch described in this embodiment is composed of a backing layer, a drug storage layer, a release-controlling film, an adhesive layer and a protective layer. The materials used for each layer are as follows:
[0103] Backing layer: aluminum foil / polyethylene composite film
[0104] Protective layer: polyester film
[0105] Controlled Release Membrane: Ethylene-vinyl acetate copolymer membrane
[0106] Adhesive layer: silicone pressure sensitive adhesive
[0107] Drug storage layer (200g):
[0108] Magnesium Isoglycyrrhizinate 20g
[0109] Carbomer 4g
[0110] Appropriate amount of triethanolamine
[0111] Glycerin 20g
[0112] Azone 4g
[0113] 5% sodium hydroxide appropriate amount
[0114] Distilled water up to 200g
[0115] Preparation method:
[0116] 1. Prepare the drug storage layer:
[0117] (1) Slowly add carbomer to 50% distilled water under stirring to ma...
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