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Doractin dashing agent and method of preparing the same

The technology of doramectin and pouring agent is applied in the field of preparation of pouring agent, which can solve the problems of large fluctuation of drug concentration, local irritation, short maintenance time, etc., and achieves low cost, avoiding degradation and low toxicity. Effect

Inactive Publication Date: 2009-04-08
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the doramectin preparations used in veterinary clinics are injections. The drug release of injections is carried out according to the first-order kinetics. It may exceed the minimum toxic concentration, and the effective blood concentration is maintained for a short time, often requiring repeated administration to achieve effective treatment and reduce side effects. Although injection administration improves bioavailability, due to subcutaneous injection to achieve the best effect It requires certain professional skills and is irritating to the local area, and it is relatively time-consuming and labor-intensive, so its promotion is limited to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] This example includes the following steps: heating 53g of absolute ethanol to 25°C, adding 0.5mg of doramectin and 0.015mg of 2,6-di-tert-butyl-p-cresol and stirring to dissolve, adding 40g of propylene glycol, 6g of azone and Tween-801g and stir well.

Embodiment 2

[0014] This example includes the following steps: heat 55.5g of absolute ethanol to 30°C, add 0.3mg of doramectin and 0.015mg of 2,6-di-tert-butyl-p-cresol and stir to dissolve, then add 40g of propylene glycol and 4g of azone Stir well with Tween-80 0.5g.

Embodiment 3

[0016] This embodiment includes the following steps: heating 42g of absolute ethanol to 30°C, adding 0.5mg of doramectin and 0.015mg of 2,6-di-tert-butyl-p-cresol and stirring to dissolve, adding 50g of propylene glycol, 6g of azone and Tween-80 2g and stir well.

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PUM

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Abstract

The invention provides a Doramectin dash agent and a preparation method thereof. The Doramectin dash agent consists of propylene glycol, anhydrous ethyl alcohol, azone, Tween-80 and 2, 6-ditertbutyl-p-cresol, wherein the azone is a percutaneous absorption accelerant for accelerating percutaneous absorption of Doramectin; the propylene glycol is a solvent, is used with the azone and has synergism for accelerating the percutaneous absorption of the Doramectin, the Tween-80 is a solubilizing agent for making the Doramectin dissolved easily, the anhydrous ethyl alcohol is an assistant agent for reducing the viscosity of the dash agent and making the dash agent permeate the skin through the clothing hair, and the 2, 6-ditertbutyl-p-cresol is an oxidation inhibitor. The Doramectin dash agent has the advantages that the Doramectin dash agent has little toxicity, lower cost and convenient use, and can be used for killing internal eelworms and external parasites of animals.

Description

(1) Technical field [0001] The invention relates to a medicine for resisting parasitic diseases, in particular to a preparation method of a pouring agent. (2) Background technology [0002] Doramectin is a broad-spectrum, high-efficiency, and non-allergic anthelmintic drug. Compared with Ivermectin, it is absorbed rapidly in animals, has a large volume of distribution in the body, and is eliminated slowly. Effectiveness. At present, most of the doramectin preparations used in veterinary clinics are injections. The drug release of injections is carried out according to the first-order kinetics. It may exceed the minimum toxic concentration, and the effective blood concentration is maintained for a short time, often requiring repeated administration to achieve effective treatment and reduce side effects. Although injection administration improves bioavailability, due to subcutaneous injection to achieve the best effect It requires certain professional skills and is irritatin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/7048A61P33/00
Inventor 宋铭忻路义鑫石艳丽韩彩霞高玉红马广鹏
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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