Force application apparatus simulating human physiological stress of tissue bionic culture for tissue engineering

Abstract

The invention discloses a force application device stimulating the human body physiological stress of bionic culture of a tissue in tissue engineering, which comprises a holder, wherein, a linear motor and a culture chamber are installed on the holder, a switch contact block and a tension and pressure transducer are installed at one end of the axle of the linear motor, a travel switch is installed on the axle housing of the motor axle, the tension and pressure transducer is connected with a connector through a coil spring and provided with a guiding axle which is inserted in the connector by passing through the coil spring and matched with the connector in a sliding way, the guiding axle has freedom of axial displacement in the connector, the culture chamber is provided with a device applying stress to culture tissue, the pole of the device applying stress to culture tissue extends out of the culture chamber and is connected with the connector and matched with the culture chamber in a sliding way. The force application device can stimulate the physiological stress and be used in the culture preparation of tissue engineering bone, gristle or tendon so as to realize the bionic culture of constructing tissue engineering bone, gristle or tendon.

Description

technical field [0001] The invention relates to the field of tissue engineering tissue culture, in particular to a force applying device for simulating human physiological stress for tissue engineering tissue bionic culture. Background technique [0002] The biomimetic culture of tissue refers to culturing tissue engineered tissue constructed by applying tissue engineering technology under in vitro culture conditions that simulate physiological stress conditions and physiological internal environment in vivo, so as to promote the structural and functional maturation of tissue engineered tissue. The simulation of physiological stress conditions in the body needs to be realized with the help of devices that can simulate physiological stress. For example, the bionic culture of tissue-engineered bone and cartilage needs to simulate physiological compressive stress on tissue-engineered bone and cartilage, and the bionic culture of tissue-engineered tendon needs to simulate physio...

AI Technical Summary

Problems solved by technology

[0005] Therefore, the existing bionic culture of tissue engineered tissue, especially the bionic culture device of tissue engineered bone, cartilage and tendon, can not apply the simulated stress that is really suitable for physiology. The promotion effect of the bionic culture of tendon and tendon is limited, and it cannot meet the requirements of its research, clinical application and industrialization. The improved design of the stress applying device for the bionic culture of tissue engineered bone, cartilage and tendon has become the focus of tissue engineering technology research in recent years. hotspot

Images