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Quality control method of Fengdima eye drops

An eye drop and detection method technology, which is applied in the directions of measuring devices, testing pharmaceutical preparations, instruments, etc., can solve problems such as the lack of quantitative measurement methods, and achieve the effects of shortening measurement time, simple method and good reproducibility

Inactive Publication Date: 2012-04-25
GENERAL HOSPITAL OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing technology can only realize the qualitative quality control of the preparation, and there is no quantitative determination method

Method used

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  • Quality control method of Fengdima eye drops
  • Quality control method of Fengdima eye drops
  • Quality control method of Fengdima eye drops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: quality control method of honeydew eye drops

[0030] 1. Materials and instruments:

[0031] Agilent 1090A High Performance Liquid Chromatograph (Agilent, USA)

[0032] Acetonitrile (chromatographically pure, Beijing Chemical Plant, batch number 20040926)

[0033] Triethylamine (analytical pure)

[0034] Sodium dihydrogen phosphate (analytical pure)

[0035] Bee Dima Eye Drops (self-made, batch number: 20060828, 20061128, 20061204)

[0036] Ephedrine hydrochloride (Chifeng Aike Pharmaceutical Technology Co., Ltd., batch number: 040404)

[0037] Tetracaine hydrochloride (Beijing Yanjing Pharmaceutical Factory, batch number: 060401)

[0038] 2. Method

[0039] (1) Feature identification:

[0040] 1. Identification of Tetracaine Hydrochloride: Take 8ml of beetle eye drops for testing, add 42ml of water, shake well; add 5ml of sodium carbonate solution (10.6g of anhydrous sodium carbonate, add water to dissolve and dilute to 100ml), shake well, Shake a...

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Abstract

The invention discloses a quality control method for Fengdima eye drops, which belongs to the pharmaceutical field. The quality control method for the Fengdima eye drops comprises: characteristic differentiation, pH value check and quantitative determination. The invention has the advantages: the emulsification phenomenon caused by honeys is overcome without influencing color development of an identified substance; the quantification can be accurately carried out, and the contents of two main components can be determined at the same time; in the determination, a gradient elution method is used, the substance to be determined can be completely separated, as well as the determination time is shortened, and a mobile phase is saved; the invention is convenient to operate and has favorable reproducibility.

Description

technical field [0001] The invention relates to a method for controlling the quality of the honeydew eye drops and belongs to the field of pharmacy. Background technique [0002] Arc-induced eye trauma, such as electro-optic ophthalmia and corneal epithelial injury, is a common and frequently-occurring disease in ophthalmology. It is common in peacetime and more common in wartime. It seriously affects people's quality of life and combat effectiveness of troops. If it is not treated in time, it can become a predisposing factor for infection. [0003] Fengdima Eye Drops is a special preparation of the General Hospital of the Chinese People's Liberation Army, providing convenient, safe, economical and effective therapeutic drugs for the treatment of war wounds and non-war electric arc eye trauma. The preparation is mainly composed of honey, tetracaine hydrochloride and ephedrine hydrochloride, and is a light brown-yellow viscous clear liquid with fragrant gas, sweet taste, slig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15G01N30/34G01N30/00G01N30/90
Inventor 孙艳郭代红栾复新刘皈阳万鲲靳守东
Owner GENERAL HOSPITAL OF PLA
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