Traditional Chinese medicine combination for treating grippe and preparation method thereof

A technology of influenza and composition, applied in the field of traditional Chinese medicine composition and its preparation, capable of solving problems such as lack of effective drugs

Active Publication Date: 2009-02-11
张文芯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Anti-influenza virus treatment is an important means of influenza control, but clinically there is basically a lack of effective drugs that directly act on the virus

Method used

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  • Traditional Chinese medicine combination for treating grippe and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Embodiment 1: dropping pill

[0131] Prescription: Chonglou 900g, Hypericum perforatum 600g

[0132] The medicinal material of Chonglou is extracted twice with 70% ethanol, the first time is extracted with 10 times the amount of reflux for 2 hours, and the second time is extracted with 8 times the amount (by weight) for 1.5 hours; the extracts are filtered and combined. Centrifuge at a speed of 2500rpm for 30min, take the supernatant, and collect the residue; the supernatant is made of AB-8 resin, the loading concentration is 0.2g / ml, the adsorption flow rate is 2BV / h, the washing volume is 5BV, and the elution volume is 5BV with 30% ethanol. The eluent is 70% ethanol, and the amount of eluent is 5.5BV, and the elution flow rate is 3BV / h; the 70% eluent is combined with the residue, the ethanol is recovered, and vacuum-dried.

[0133] Hypericum perforatum was extracted twice with 80% ethanol, 2.0 hours each time, 10 times the amount; the extracts were filtered and comb...

Embodiment 2

[0137] Prescription: Chonglou 1000g, Hypericum perforatum 600g

[0138] The medicinal material of Chonglou is extracted twice with 70% ethanol, the first time is extracted with 11 times the amount of reflux for 2 hours, and the second time is extracted with 9 times the amount (weight ratio) for 1.5 hours; the extracts are filtered and combined. Centrifuge at a speed of 2500rpm for 30min, take the supernatant, and collect the residue; the supernatant is made of AB-8 resin, the loading concentration is 0.2g / ml, the adsorption flow rate is 2BV / h, the washing volume is 5BV, and the elution volume is 5BV with 30% ethanol. The eluent is 70% ethanol, and the amount of eluent is 5.5BV, and the elution flow rate is 3BV / h; the 70% eluent is combined with the residue, the ethanol is recovered, and vacuum-dried.

[0139] Hypericum perforatum was extracted twice with 80% ethanol, 2.0 hours each time, 10 times the amount; the extracts were filtered and combined. Centrifuge at a speed of 25...

Embodiment 3

[0142] Chonglou 900g, Hypericum perforatum 600g;

[0143]The original medicinal material is decocted with water for 3 times, each time the amount of water is 8 times the amount of medicinal material (weight ratio), each extraction is 1.5 hours, the combined extract is filtered to obtain the extract; the above extract is filtered, and the filtrate is passed through Macroporous resin, first elute with ethanol with a concentration below 20%, discard the eluent, then add 70% ethanol for 5 times elution, collect the eluent, recover ethanol under reduced pressure until there is no alcohol smell, and obtain a purified extract , dried, crushed into fine powder, and added to the molten matrix PEG4000:6000=3:1 (melting temperature 70°C), wherein the ratio of matrix to drug is 1:1. The condensing agent is methyl silicone oil-50; the dripping temperature is 65-75°C (75°C), the drop distance is 6cm, the length of the cooling column is 50cm, and the condensation temperature is ice water bat...

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Abstract

The invention discloses a traditional Chinese medicine combination for curing influenza and a preparation method thereof. The combination is prepared from rhizome paridis and hypericum perforatum or from the extract products of rhizome paridis and hypericum perforatum. The traditional Chinese medicine combination is a medicine for resisting H1N1 virus and H3N2 virus with high efficacy and low toxin, and has excellent effect in curing influenza.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating influenza and a preparation method thereof. Background technique [0002] Influenza is an acute respiratory infectious disease caused by influenza virus, and is one of the major public health problems faced by human beings. According to statistics, the annual incidence of influenza is 10% to 30%. The most notable epidemiological features are: sudden outbreak, rapid spread, and wide spread; influenza epidemic has a certain seasonality, and it often occurs in winter in northern my country. , while the south mostly occurs in winter and summer; the incidence of influenza is high, and the population is generally susceptible. Influenza has severe clinical symptoms, rapid onset, high incidence of complications, and can cause death. Most of the deaths are elderly and frail, young and sick...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/20A61P31/16
Inventor 张文芯杨培民
Owner 张文芯
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