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Use of carthamus tinctorius yellow colour in preparing medicine for treating and/or preventing myocardial apoptosis

A technology of cardiomyocyte apoptosis and safflower yellow pigment, applied in the field of safflower yellow pigment, can solve the problems of cardiomyocyte apoptosis that have not been reported yet

Inactive Publication Date: 2009-02-04
BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many reports on the efficacy of safflower in alleviating myocardial ischemia, the study on safflower yellow in alleviating cardiomyocyte apoptosis and inhibiting the expression of cardiomyocyte apoptosis genes has not been reported yet.

Method used

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  • Use of carthamus tinctorius yellow colour in preparing medicine for treating and/or preventing myocardial apoptosis
  • Use of carthamus tinctorius yellow colour in preparing medicine for treating and/or preventing myocardial apoptosis
  • Use of carthamus tinctorius yellow colour in preparing medicine for treating and/or preventing myocardial apoptosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Preparation of Safflower Yellow by Macroporous Resin-Gel Column Chromatography

[0077] Experimental Materials

[0078] Safflower raw medicine was purchased from Urumqi Medicinal Materials Company of Xinjiang Uygur Autonomous Region, and its origin is Jimsar County, Xinjiang Uygur Autonomous Region. The authenticator, Professor Li Jiashi, Department of Pharmacognosy, School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, is the dried flower of Carthamustinctorius L., a safflower of Compositae. 95% sanitation alcohol is produced by Beijing Yuanhong Medicinal Alcohol Co., Ltd.; D-4020 type non-polar macroporous resin is a product of Tianjin Nankai University Chemical Factory; Porous resins such as D-3520, X-5, NKA-9, etc. Newly purchased macroporous resin is soaked in 5% NaOH solution for 2 hours, washed with water until neutral, then soaked in 5% HCl for 2 hours, washed with water until neutral, wet-packed, washed with 95% ethanol until t...

Embodiment 2

[0088] Safflower Yellow Oral Hard Capsules

[0089] Safflower Yellow 100g

[0090] 100g dry starch

[0091] The above components are mixed and packed into 1000 hard capsules to obtain oral hard capsules of safflower yellow

Embodiment 3

[0093] Safflower Yellow Injection

[0094] Safflower yellow pigment 50g

[0095] Appropriate amount of water for injection

[0096] Full volume 1000ml

[0097] Take 50 grams of safflower yellow and dissolve it with an appropriate amount of water for injection and add it to 1000 milliliters to prepare the safflower yellow injection by filling and sealing according to a conventional method.

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Abstract

The invention discloses the new application of carthamus tinctorius yellow colour which is prepared by extracting traditional Chinese safflower, namely, the new application on preparing medicines which cure and / or prevent the death of cardiac muscle cells; the invention also discloses medicines prepared by the carthamus tinctorius yellow colour and formulations thereof.

Description

Technical field: [0001] The present invention relates to a new application of safflower yellow extracted and prepared from traditional Chinese medicine safflower, that is, a new application in the preparation of drugs for treating and / or preventing cardiomyocyte apoptosis, and a pharmaceutical composition composed of the above-mentioned safflower yellow. Background technique: [0002] With the development of economy and society, cardiovascular and cerebrovascular diseases have increasingly become an important issue affecting people's life and health. In many cardiovascular diseases such as coronary heart disease, hypertension and cardiomyopathy, cardiomyocyte apoptosis plays an important role in the pathophysiological changes. Different from the mechanism of ischemic cardiomyocyte necrosis, cardiomyocyte apoptosis is another way of myocardial ischemia-induced cell damage. Once the cardiomyocyte damage starts the apoptosis program, the cardiomyocyte will go to an irreversible...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/351A61P9/10A61P9/04
Inventor 金鸣董宁宁吴伟臧宝霞童静李金荣
Owner BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
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