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Medicament composition for treating rheumatoid arthritis

A rheumatoid, composition technology, applied in the directions of drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve the problems of no ideal and efficient treatment method, difficult to cure, and long course of rheumatoid arthritis

Active Publication Date: 2009-01-21
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Rheumatoid arthritis has a long course of disease, shows chronic progression, and has a high disability rate. The pathological process is like a malignant tumor, and it is difficult to cure. So far, there is still no ideal and efficient treatment method at home and abroad, especially in drug treatment.

Method used

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  • Medicament composition for treating rheumatoid arthritis
  • Medicament composition for treating rheumatoid arthritis
  • Medicament composition for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Grind 600 g of Aescinus stems and leaves into coarse powder, heat and reflux with ethanol for at least 3 times, combine the extracts, recover ethanol, concentrate and dry to obtain extract powder of Aescinus stems and leaves extract; grind 8000 g of Andrographis paniculata, and use Extract with ethanol, obtain the extract with andrographolide as the main index, the extract is pulverized, and cross a sieve greater than 180 mesh; add the extract of Aesculus chinensis stem and leaf after dissolving menthol 6g and bacteriostatic agent with 95% ethanol Paste powder, then dissolved in a solvent, added crushed and sieved Andrographis paniculata extract and mixed evenly; fully stirred and mixed with gel matrix carbomer, triethanolamine and glycerin to obtain a gel;

Embodiment 2

[0063] Grind 576g of Aescinus stems and leaves into coarse powder, heat and reflux extraction with ethanol for at least 3 times, combine the extracts, recover ethanol, concentrate and dry to obtain extract powder of Aescinus stems and leaves extract; grind 7680g of Andrographis paniculata with Extract by supercritical extraction method to obtain the extract with andrographolide as the main index, crush the extract and pass through a sieve larger than 180 mesh; dissolve 4 g of menthol with 95% ethanol and add the extract of the stem and leaf of Aesculus aescini Powder, then dissolve with solvent, add the Andrographis paniculata extract that has been pulverized and sieved and mix uniformly; Add an appropriate amount of ethanol and 368g of propane butane to prepare 1000ml of medicinal solution, which obtains the aerosol of the present invention.

Embodiment 3

[0065] Grind 624g of Aescinus stems and leaves into coarse powder, heat and reflux extraction with ethanol for at least 3 times, combine the extracts, recover ethanol, concentrate and dry to obtain extract powder of Aescinus stems and leaves extract; grind 8320g of Andrographis paniculata with After ethanol extraction, pass through a macroporous resin column to obtain an extract with andrographolide as the main index, crush the extract, and pass through a sieve larger than 180 mesh; dissolve 8 g of menthol with 95% ethanol and add Aesculus aesculus stems and leaves to extract Extract powder, dissolve with solvent again, add the Andrographis paniculata extract that has been pulverized and sieved and mix evenly; Add appropriate amount of ethanol, 47g of glycerin, 40188g of drug film resin, make 1000g of drug solution, obtain the coating film of the present invention agent.

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Abstract

The present invention pertains to the field of medicine technology and discloses a medicine combination for curing rheumatoid arthritis. The combination contains the raw materials with the following weight rate: 7,680 to 8,320 portions of Common Andrographis Herd, 576 to 624 portions of scandent schefflera stem and leaf , 4 to 8 portions of menthol and the rest of auxiliary materials; the Common Andrographis Herd of the combination can be replaced by the extract andrographolidume of Common Andrographis Herd and scandent schefflera stem and leaf can be replaced by stem and leaf extract; the weight rate of Common Andrographis Herd extract, scandent schefflera stem and leaf extract and menthol is as follows: 48 to 112 portions of andrographolidume, 40 to 94 portions of scandent schefflera stem and leaf extract, 4 to 8 portions of menthol and the rest of auxiliary materials.

Description

technical field [0001] The invention relates to a pharmaceutical composition capable of treating rheumatoid arthritis Background technique [0002] Rheumatoid arthritis is a chronic, inflammatory, systemic autoimmune disease. It is a common clinical disease and frequently-occurring disease, which seriously affects people's normal work and life. Some patients will remain bedridden for a long time because of this disease. Lead to paralysis, etc.; manifested as joint persistent and progressive synovitis, and then cause cartilage destruction and bone erosion, resulting in joint deformity and disability. Traditional Chinese medicine calls it "arthromyopathy", which is caused by wind, cold, dampness, heat and other exogenous evils invading the human body and blocking the meridians, resulting in poor circulation of qi and blood. Common rheumatoid arthritis are: rheumatism, rheumatoid arthritis, rheumatic cold arthralgia, gout, proliferative arthritis, periarthritis of shoulder. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61K9/00A61K9/12A61K9/70A61P19/02A61P29/00A61K31/045
Inventor 王明辉朱兆云徐榕雪崔涛王京昆刘波
Owner YUNNAN INST OF MATERIA MEDICA
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