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Chinese medicine compound volatile oil part for treating asthma and preparation thereof

A technology of volatile oil and compound recipe, which is applied to the volatile oil part of the traditional Chinese medicine compound recipe for treating asthma and its preparation, the effective part of the Chinese medicine compound recipe and its preparation, and the application fields in the preparation of medicines for the treatment of asthma, which can solve the problems of inconvenient use and inaccurate effect parts, etc. , to achieve the effect of clear effective site, good reproducibility and prolonging the incubation period of asthma

Active Publication Date: 2008-12-17
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from the current clinical treatment of asthma, combining syndrome differentiation and disease differentiation, traditional Chinese medicine has increasingly shown its unique therapeutic advantages, but there are problems of inconvenient use and unclear effect sites

Method used

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  • Chinese medicine compound volatile oil part for treating asthma and preparation thereof
  • Chinese medicine compound volatile oil part for treating asthma and preparation thereof
  • Chinese medicine compound volatile oil part for treating asthma and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 A preparation method of the volatile oil part of a traditional Chinese medicine compound, the steps are as follows:

[0026] Take 40g of licorice, 60g of ephedra, 100g of bitter almond, 100g of pinellia, 200g of raw gypsum, 100g of fine tea, and 60g of schisandra to form a total of 660g. After crushing, put it in a 20000mL round-bottomed flask, add 10 times the amount of pure water, After shaking and mixing, soak for 30 minutes;

[0027] Connect the volatile oil extractor to the reflux condenser. Add water from the upper end of the condensing tube to fill the scale part of the volatile oil tester until it overflows into the flask. Put it in an electric heating mantle and heat it slowly to 110°C to boil, and keep boiling for 8 hours until the oil volume in the tester no longer increases, stop heating, let it stand for a while, open the lower piston of the tester, and slowly release the water until the upper end of the oil layer reaches 5mm above the 0 line...

Embodiment 2

[0028] Embodiment 2 A preparation method of Chinese medicine compound volatile oil, the steps are as follows:

[0029] Take 80g of licorice, 120g of ephedra, 200g of bitter almond, 200g of pinellia, 400g of raw gypsum, 200g of fine tea, and 120g of schisandra, making up a total of 1320g of the whole formula. After crushing, put it in a 20000mL round bottom flask, add 10 times the amount of pure water, and shake After mixing, soak for 30min.

[0030] Connect the volatile oil extractor to the reflux condenser. Add water from the upper end of the condenser tube to fill the scale part of the volatile oil extractor until it overflows into the flask. Put it in an electric heating mantle and heat it slowly to 110°C boiling, and keep boiling for 8 hours until the oil volume in the extractor no longer increases, stop heating, let it stand for a while, open the lower piston of the extractor, and slowly release the water until the oil layer reaches the upper end 5mm above the 0 line on...

Embodiment 3

[0031] Example 3 The experimental research on the treatment of asthma by the volatile oil part of the traditional Chinese medicine compound provided by the present invention

[0032] The present invention is to the drug effect of guinea pig egg protein asthma model, concrete experimental result is as follows:

[0033] Choose healthy guinea pigs, weighing 250±20g, half male and half male. They were randomly divided into blank group, model group and volatile oil group.

[0034] (1) Chinese medicine compound volatile oil provided by the present invention has influence on latent period and behavior of causing wheezing

[0035] Table 1 The influence of traditional Chinese medicine compound volatile oil on the incubation period and behavior of guinea pigs (X±SD, n=8)

[0036]

[0037]

[0038] Compared with the normal control group and the model group, ##P<0.01; compared with the drug treatment group and the model group, *P<0.05, **P<0.01.

[0039] The results showed that c...

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Abstract

The invention discloses a Chinese herbal compound volatile oil part for treating asthma and a preparation method thereof. The Chinese herbal compound volatile oil part is extracted by steam distillation from a crude drug which is made from licorice, Chinese ephedra, bitter apricot kernel, pinellia tuber, gypsum, tea bust and Chinese magnolivine fruit according to certain weight proportion by parts with the yield of 0.17%. The Chinese herbal compound volatile oil part has the advantages of simple preparation process, good reproducibility and low cost. Pharmacological tests prove that the Chinese herbal compound volatile oil part of the invention can obviously prolong the incubation period of asthma in animals, reduce the responsiveness of asthma airway, improve the ethological sign of asthma, obviously decrease EOS in BALF, inhibit the aggregation of main inflammatory cells EOS in lung tissues, obviously inhibit the level of inflammatory factors IL-4 and IL-5 in serum, improve the level of IFN-Gamma in serum, and regulate the balance relationship of Th1 / Th2, therefore, the Chinese herbal compound volatile oil part of the invention is ideal for preparing the medicine for treating asthma.

Description

1. Technical field [0001] The invention relates to an effective part of a compound Chinese medicine and a preparation method thereof, in particular to a volatile oil part of a Chinese medicine compound for treating asthma and a preparation method thereof, as well as its application in preparing medicines for treating asthma, belonging to the field of traditional Chinese medicine. 2. Background technology [0002] Bronchial asthma (asthma for short) is a common respiratory disease. In recent years, the morbidity and mortality of asthma in many countries and regions have been increasing year by year. There are at least 100 million people in the world suffering from asthma. The total prevalence of asthma in developed countries Up to 7% to 8%, my country is about 1% to 2%. Therefore, the prevention and treatment of asthma has been paid attention by the World Health Organization and governments of various countries, and has become the most active research field in respiratory dise...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P11/06A61K33/06
Inventor 范欣生唐于平徐惠琴徐立王明艳
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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