Tetrodotoxin formulation for drug rehabilitation , pain ease

Abstract

The present invention relates to a tetrodotoxin preparation used for drugs abstinence and analgesia. The preparation comprises small dose of tetrodotoxin that is taken as active ingredient of medicine and cosolvent or allowable supportting agent in pharmacy. The cosolvent is amino acid. In the present invention, the amino acid is taken as the cosolvent, which not only can act as the cosolvent forincreasing solubility of the tetrodotoxin in water, but also can form highly water-soluble salting liquid with the tetrodotoxin. The tetrodotoxin used in the present invention is prepared by adoptingthe specific method of the present invention. The purity of the prepared tetrodotoxin is as high as 98 percent with high yield. The preparation formed by the tetrodotoxin prepared by adopting the method provided in the present invention and amino acid is not only good in water solubility, but also good in stability, safe, reliable, stable in quality. The preparation does not need to be preserved in the refrigerator at specific temperature. The preparation can be preserved for more than 2 years at room temperature, thus greatly saving storage and transportation cost and providing convenience for use in medical treatment. The cure effect is evident, and in particular when applied to physiologic de-toxin, the tetrodotoxin preparation has a cure rate reaching 100 percent.

Description

Tetrodotoxin preparation for detoxification and analgesia technical field The invention belongs to the field of pharmaceutical preparations, in particular to a tetrodotoxin preparation for detoxification and analgesia. Background technique Tetrodotoxin (TTX) is a low molecular weight alkaloid extracted from the viscera of puffer fish. Due to its unique chemical structure, it is a specific blocker of sodium ion channels in cells. Therefore, it has an irreplaceable position as a biological reagent in the field of biological research. The pharmacological effects of tetrodotoxin in clinical medicine have been reported as early as the 1930s for the clinical intervention of alkaloid addiction. There are also continuous reports on analgesic treatment. Therefore, it plays a very important role both in the field of biological research and in the clinical application of medicine. TTX is a very useful tool drug for neurophysiological research because it can block the channel of ...

AI Technical Summary

Problems solved by technology

However, the absorption rate of nasal mucosa is affected by many factors

And the acid used in the examples of this patent is a buffering agent, and the number of moles of the acid used in the preparation shows that most of the TTX still has not formed a salt, that is, most of the TTX still cannot form a highly water-soluble solution, and cannot fundamentally solve the problem of its water solubility. question

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