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Southernwood total flavone, method for preparing its composition and medicine uses thereof

The technology of total flavonoids and compositions is applied in the field of preparation of total flavonoids of Artemisia annua and compositions thereof, which can solve the problems such as the preparation method and medicinal use of total flavonoids of Artemisia annua, which have not been seen yet, and achieve remarkable pharmacological activity and production cost. Low, process stable effect

Inactive Publication Date: 2008-12-03
薛永新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there have been no relevant reports on the preparation method and medical use of the total flavonoids of Artemisia annua and its composition with Artemisia annua oil

Method used

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  • Southernwood total flavone, method for preparing its composition and medicine uses thereof
  • Southernwood total flavone, method for preparing its composition and medicine uses thereof
  • Southernwood total flavone, method for preparing its composition and medicine uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation of total flavonoids of Artemisia annua: take 1 kg of Artemisia annua medicinal material and crush it into 20 mesh coarse powder, add 60% ethanol aqueous solution of 6 times the weight of medicinal material, heat and reflux for extraction twice, each time for 1.5 hours, filter, combine extracts, and decompress Recover the solvent to 1g crude drug / mL. Pass the concentrated solution through the activated D141 macroporous resin column, so that the flavonoids in the liquid are absorbed by the resin column, discard the effluent, wash with distilled water of 3 times the column volume, discard the effluent, and continue to use 95 % ethanol to elute the resin column until the flavonoids adsorbed on it are completely eluted, and the eluate is collected and dried under reduced pressure to obtain 25.3 g of tan powder of total flavonoids of Artemisia annua.

Embodiment 2

[0021] Preparation of the total flavonoids of Artemisia annua: Take 1 kg of the remaining medicinal residues of artemisinin extracted from Artemisia annua, add 8 times the weight of medicinal materials in 70% ethanol aqueous solution, heat and reflux for 3 times, each time for 1.0 hour, filter, combine the extracts, Recover the solvent under reduced pressure to 1 g crude drug / mL. Pass the concentrated solution through the activated D101 macroporous resin column, so that the flavonoids in the liquid are absorbed by the resin column, discard the effluent, rinse with distilled water of 3 times the column volume, discard the effluent, and continue to use 95 % ethanol to elute the resin column until the flavonoid components adsorbed on it are completely eluted, and the eluate is collected and dried under reduced pressure to obtain 23.7 g of yellow-brown total flavonoid powder of Artemisia annua. The D101 macroporous resin described in this example can also be replaced by other non-...

Embodiment 3

[0023] Preparation of total flavonoids of Artemisia annua: take 1 kg of Artemisia annua and crush it into 40-mesh powder, add 60% ethanol 10 times the weight of the medicinal material, ultrasonically extract 3 times, 20 min each time, filter, combine the extracts, and recover the solvent to 1 g under reduced pressure Crude drug / mL. Add 1 / 2 of ethyl acetate to the concentrated solution, shake the two phases fully for extraction, extract 3 times, collect the ethyl acetate solution, dry under reduced pressure to obtain tan powder of total flavonoids of Artemisia annua 12.5g.

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Abstract

The invention belongs to the Chinese traditional medicine preparation method and the application field, in particular relating to a method for preparing southernwood total flavone and a composition thereof and a medicinal application thereof. The preparation method comprises the following steps that: the whole strain or branches and leaves or rootstalks of southernwood or medical dregs left after artesunate is extracted from the southernwood are used as raw materials, the raw materials are extracted by water or / and alcohols, the obtained extracting solution is subject to filtering and concentration, the obtained concentrates are separated by macroporous resins or extracted and separated by organic solvents, the eluents or extract liquor are concentrated and dried to prepare the southernwood total flavone, and the southernwood total flavone can be used to prepare medicines for treating and preventing tumors, arteriosclerosis, AIDS, flu, herpes, hepatitis and inflammatory reactions caused by pathogenic microbes, or be applied to products related to the diseases. The invention also relates to a medicinal application of a composition in resisting tumors, resisting cardiovascular diseases, resisting inflammation, relieving pain, reducing heat, regulating immunity and resisting bacteria and viruses, wherein the composition comprises 10 to 90 portions of the southernwood total flavone and 90 to 10 portions of artemisia oil.

Description

Technical field: [0001] The invention belongs to the field of preparation method of traditional Chinese medicine and the application field of traditional Chinese medicine, and specifically relates to a preparation method and medical application of total flavonoids of Artemisia annua and its composition. Background technique: [0002] Artemisia annua is the dry aboveground part of Artemisia annua L. of Compositae, which grows in wilderness, hillside, roadside and river bank, and is distributed all over the country. Traditional Chinese medicine believes that Artemisia annua has the effects of clearing heat and detoxifying, eliminating steam, and abstaining from malaria. Most of the reports on Artemisia annua are about the antimalarial effect and extraction process of artemisinin. But so far, there is no related report about the preparation method and medical use of the total flavonoids of Artemisia annua and its composition with Artemisia annua oil. Invention content: [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61K31/352A61K31/7048A61P1/16A61P9/10A61P9/12A61P31/00A61P31/14A61P31/16A61P29/00A61P31/18A61P31/20A61P31/22
Inventor 薛永新
Owner 薛永新
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