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Process for preparing tripterine

A technology of tripterine and chloroform, applied in the direction of steroids, organic chemistry, etc., can solve the problems of unsuitable industrial production and many steps, and achieve the effect of safe extraction method

Inactive Publication Date: 2008-11-26
SHENZHEN PAIPAI TECH
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Problems solved by technology

Reference [6] discusses the method of separating and purifying tripteryne and its analogues twice with a silica gel column, but using a solvent system n-hexane to gradually increase the ratio of ethyl acetate to separate and purify tripteryne, the steps Too much, not suitable for industrial production

Method used

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Embodiment Construction

[0023] 1. Washing, air-drying and pulverizing the root bark of Euonymus plants to obtain plant powder, drying at 80°C until the weight loss on drying is less than 6%;

[0024] 2. Put 10 kg of plant powder into the ultrasonic extraction device, add 30-50 kg of chloroform, ultrasonically extract at 20-45°C for 15-25 minutes, filter the chloroform extraction solution, repeat the above steps of extracting plant powder twice, and combine chloroform extraction solution;

[0025] 3. Concentrate the chloroform extraction solution under reduced pressure to obtain 0.3-0.6 kg of chloroform extract;

[0026] 4. Add 5-8 kg of petroleum ether (boiling range 60-90°C) to the chloroform extract, heat to reflux for 1 hour, filter out the petroleum ether while it is hot, and repeat the above steps once to obtain 0.2-0.3 kg of de-lowering pole Sexualized chloroform extract;

[0027] 5. Dissolve the chloroform extract with 0.4-0.9 kg of chloroform to obtain a chloroform solution, and slowly add ...

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Abstract

The invention provides a preparation method for celastrol, which relates to the preparation method for extracting, separating and purifying the celastrol from the root bark of celastraceae plants. The method is characterized in that the method improves the weakness of being incapable of separating high-purity celastrol of the traditional column chromatography method (LC), which can prepare the celastrol with more than 99 percent of purity and reduce the weakness of high-cost investment of the equipment and small preparation amount at a time of the current countercurrent chromatography (CCC) method. The method can be used in industry for producing the high-purity celastrol, which uses the technical characteristics of chloroform ultrasonic extraction, double-solvent elution silica gel column chromatography, component solvent recrystallization, and the like, and is characterized by high extraction rate, high purity, easy operation, safety, reliability, low cost, industrial suitability, etc. The prepared celastrol can reach the quality standard of bulk drug of national primary new drugs, which has the usages of scientific research, standard, etc.

Description

technical field [0001] The patent of the present invention "a preparation method of tripterygne" relates to a preparation method for extracting, separating and purifying tripteryne from the root bark of Euonymus plants. The characteristics of this method promptly improve the weakness of the traditional column chromatography (LC) method that can not separate out high-purity tripterine, can prepare tripterylide with a purity greater than 99%, and reduce the cost of modern countercurrent chromatography (CCC) ) equipment with high cost input and a small amount of one-time preparation, the method can be used for industrial production of high-purity tripterine. Background technique [0002] References [1] "Preparation method of crude extract of Tripterygium wilfordii" Patent Application No. CN02155133.2 describes a method for preparing crude extract of Tripterygium wilfordii. Extraction in a low-temperature jacket until the active ingredients are extracted completely, the extract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
Inventor 袁晓周东斌卢大炎袁萍
Owner SHENZHEN PAIPAI TECH
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