Uses of 3-hydroxy fatty acid and its derivative in preparing calcium ion duct modifying agent

Abstract

The invention provides an application of 3-hydroxy fatty acid and derivatives thereof in the preparation of calcium ion channel regulator. An in vitro test indicates that the calcium ion channel regulator promotes neuroglia cell growth and activates cell calcium ion channel; and can be used for treating disease correlated to insufficient activation of the calcium ion channel, and used for culturing cell in vitro, particularly neuroglia cell.

Description

Use of 3-hydroxy fatty acid and its derivatives in the preparation of calcium ion channel regulators technical field The invention relates to the field of biopharmaceuticals, more specifically, the use of 3-hydroxy fatty acid and its derivatives in preparing calcium ion channel regulators. Background technique Intracellular Calcium Introduction The change of intracellular free calcium ion concentration is the main way for animal cells to transmit information from the outside of the cell to the relevant site in the cell. At the same time, the change, location, and duration of Ca2+ concentration all represent the signaling process of intracellular calcium ions. The increase of calcium ion concentration in a certain area of ​​the cell is usually caused by the binding of extracellular signaling molecules (such as antagonists) to receptors on the cell membrane, thereby causing signal transmission. The increase of Ca2+ concentration in the cytoplasm can be caused by calcium i...

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Problems solved by technology

Because there are many types of RACCs, and each cell contains many kinds of RACCs, and each RACCs has its own differences in physiological functions, electrophysiological properties, structures and activation mechanisms, so the current understanding of RACCs is not yet complete. Very thorough (Barritt.BiochemJ, (1999) 337, 153)

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