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Process for abstracting high-purity tanshinol form salvia

A high-purity technology of danshensu, which is applied in the field of herbal medicine, can solve the problems of increasing the chance and content of organic solvent residues, which is not conducive to industrialization, and high production costs, and achieves the effects of low cost, prevention of oxidative deterioration, and low pollution

Active Publication Date: 2008-10-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process of the above methods is complicated, and the chromatographic column separation is used many times, which increases the chance and content of organic solvent residues, and the use of extraction, ultrafiltration and other methods is not conducive to industrialization and high production costs

Method used

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  • Process for abstracting high-purity tanshinol form salvia
  • Process for abstracting high-purity tanshinol form salvia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 5 kg of Danshen slices, crush them, add 75 L of sodium hydroxide solution with a pH of 8, extract by hot dipping at 60°C for 3 times, each time for 0.5 h, and combine the extracts for 3 times. Adjust the pH to 1 with dilute hydrochloric acid, at this time a large amount of precipitate precipitated, which was removed by filtration. Concentrate the supernatant under reduced pressure at 60°C to 2000ml, add ethanol and stir thoroughly, and make the alcohol concentration reach 70%. After standing at room temperature for 24 hours, filter out the precipitate, and concentrate the filtrate under reduced pressure until it has no alcohol smell. The 5kg AB-8 macroporous resin column on the concentrated solution is first washed with 2 times the volume of water, and this part is impurity components, which is treated separately; then washed with 3 times the volume of water to collect this part. Concentrate the aqueous solution under reduced pressure at 60°C to about 500ml, add pH...

Embodiment 2

[0030] Take 10 kg of Danshen slices, crush them, add 120 L of potassium hydroxide solution with a pH of 10, heat-dip and extract twice at 80°C for 1 hour each time, and combine the two extracts. The pH was adjusted to 2 with acetic acid, at which point a large amount of precipitate precipitated, which was removed by filtration. The supernatant was concentrated under reduced pressure at 70°C to 3000ml, added ethanol and stirred thoroughly, and the alcohol concentration reached 85%. After standing at 4°C for 18 hours, the precipitate was filtered off, and the filtrate was concentrated under reduced pressure until it had no alcohol smell. The 10kg HP-20 macroporous resin column on the concentrated solution is first washed with 2 times the volume of water, and this part is impurity components, which is treated separately; then washed with 5 times the volume of water to collect this part. Concentrate the aqueous solution under reduced pressure at 70°C to about 500ml, add potassium ...

Embodiment 3

[0032]Take 2 kg of Danshen slices, crush them, add 20 L of ammonia solution with a pH of 9, heat soak and extract at 75°C for 3 times, each time for 1 hour, and combine the extracts for 3 times. Adjust the pH to 1.5 with dilute sulfuric acid, at this time a large amount of precipitate precipitated, which was removed by filtration. Concentrate the supernatant under reduced pressure at 65°C to 1000ml, add ethanol and stir thoroughly, and make the alcohol concentration reach 75%, let it stand at 4°C for 12 hours, filter out the precipitate, and concentrate the filtrate under reduced pressure until it has no alcohol smell. The 2kg D101 macroporous resin column on the concentrated solution is first washed with 3 times the volume of water, and this part is impurity components, which is treated separately; then washed with 4 times the volume of water to collect this part. Concentrate the aqueous solution under reduced pressure at 60°C to about 500ml, add ammonia solution of pH 9 to a...

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Abstract

The invention belongs to the technical field of plant drugs, and particularly relates to a method for extracting danshensu with high-purity from Salvia miltiorrhiza, which comprises the following steps: extracting solution is extracted from the Salvia miltiorrhiza medicine material containing danshensu by using a hot dripping method; the pH value of the extracting solution is adjusted by acid, the impurities are cleared and concentrated in a pressure reducing way; the eluting is carried out by using a macro porous adsorption resin and the danshensu is enriched; then concentration is carried out at low temperature, freezing and drying are carried out into solid; finally, ethanol is used for heating and dissolving, and the filter liquor is concentrated at low temperature after being filtered and precipitated, a crystallization is precipitated and the danshensu is obtained and the purity of the danshensu is more than 90 percent. The method for extracting danshensu with high-purity from Salvia miltiorrhiza has simple technology, high extracting efficiency, little pollution and low production cost, which can be controlled and is suitable for mass production.

Description

technical field [0001] The invention belongs to the technical field of herbal medicines, and in particular relates to a method for extracting high-purity danshensu from salvia miltiorrhiza. Background technique [0002] Salvia miltiorrhiza Bumge is a perennial herb of the Lamiaceae genus Salvia. It is a traditional Chinese medicine in my country. It has the effects of promoting blood circulation and removing blood stasis, dredging channels and collaterals, clearing heart and eliminating troubles. It is listed as the top grade in "Shen Nong's Herbal Classic". There are two main types of active ingredients in Salvia miltiorrhiza: one is fat-soluble ingredients represented by tanshinone; the other is water-soluble ingredients represented by salvianolic acid. Studies have shown that the water-soluble components of Salvia miltiorrhiza have anti-oxidation, anti-coagulation, anti-thrombotic, anti-cardiovascular and cerebrovascular ischemia and blood lipid regulation effects, and ha...

Claims

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Application Information

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IPC IPC(8): C07C59/52C07C51/42A61K36/53
Inventor 张川邹豪张宁
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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