Anticancer sustained-release gel injection containing taxone medicine

Abstract

A sustained-release gel injection comprises sustained-release microspheres containing taxanes drug, amphiphilic block copolymer, solvent and release regulator, wherein the mixture of the amphiphilic block copolymer and the solvent has a temperature sensitive gelatinization characteristic, and can automatically become non-flowing degradable water insoluble gel, which can locally and slowly release drug at tumor foci for several weeks to several months, after injection into body. The preparation can be injected into or around a tumor for treating solid tumors at different stages. The preparation has the effects of controlling residual tumor cells relapsed after operation and tumors that can not be excised via operation, controlling complications at late stage of tumors, and enhancing treatment effect of chemotherapy and radiotherapy (particularly radioactive particles). The taxanes are selected from docetaxel, taxol, epitaxol, hydroxyl taxol and deacetyltaxol; the amphiphilic block copolymer is PLGA-PEG-PLGA copolymer, wherein the PEG has molecular weight of 1200-1600, accounting for 20 wt% of the amphiphilic block copolymer; and in the glycolide-lactide copolymer, the mol ratio of glycolide and lactide is 6:1.

Description

Anti-cancer slow-release gel injection containing taxanes (1) Technical field The invention relates to an anticancer slow-release gel injection containing taxane drugs, belonging to the technical field of medicines. Specifically, the invention relates to a slow-release gel preparation capable of stably releasing taxane drugs and / or slow-release microspheres in local solid tumors, mainly a slow-release gel injection. It is an aqueous solution at room temperature, and can become a semi-solid or solid gel in the body of a warm-blooded animal, wherein the taxane drugs are partially or completely encapsulated in the slow-release microspheres, and the taxane drugs contained in the slow-release microspheres The local slow release time of the tumor is further extended to several months. (2) Background technology Although there are many ways to treat cancer, the living conditions of most patients have not been significantly improved. Among the various treatments, chemotherapy, su...

AI Technical Summary

Problems solved by technology

Therefore, in most cases, the final sustained-release formulations are mostly solid shapes (eg, microspheres, tablets, or rods), which require a more complicated implantation process, and are prone to tissue trauma and even tumor cell seeding or dissemination

Solid implants cannot effectively cover the irregular tumor cavity after tumor resection, so the residual tumor cells cannot be effectively removed after surgery, and postoperative recurrence cannot be effectively controlled

In addition, organic solvents or high heat processes often lead to the degradation and denaturation of many anti-cancer active ingredients

In addition, the existing sustained-release preparations have obvious burst release, and the release cycle is short, which is not ideal for slow-growing tumors, especially cells in the G0 phase

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