Method of inhibiting the proliferation and migration of helicobacter pylori

A technology of Helicobacter pylori and movement, which is applied in the field of inhibiting the proliferation and movement of bacterial strains, can solve the problems of side effects of resistant bacteria, unclear effect of antibacterial agents, no proliferation inhibition, movement inhibition, etc., and achieve the effect of inhibiting proliferation

Inactive Publication Date: 2008-09-24
AKO KASEI CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, the strains of Helicobacter pylori (Helicobacter pylori) are different depending on the host, so the effect of using general antibacterial agents is not clear, or the current situation is an example of unsuccessful sterilization due to the emergence of resistant bacteria and side effects increasing
[0014] Therefore, Patent Document 11 (Japanese Patent Application Laid-Open No. 10-33179 ) describes an effective probe for infection diagnosis in the detection and identification of Helicobacter pylori strain itself, and Patent Document 12 (Japanese Patent Application Laid-Open No. 10-87512 No. 2001-285099 publication) and patent document 14 (Japanese Patent Application Publication No. 2001-321197 ) describes primers focusing on Helicobacter pylori (Helicobacter pylori) strain genes and an inspection method for clarithromycin resistance of Helicobacter pylori (Helicobacter pylori) strains, Patent Document 15 (Japanese Patent Application Laid-Open Publication No. 11-318490) A method for detecting urease derived from Helicobacter pylori (Helicobacter pylori) strains is described in , and there have been many reports on simple detection and identification methods for Helicobacter pylori (Helicobacter pylori) strains, but there is no use of deep ocean water for its proliferation. Inhibition, motor inhibition reported

Method used

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  • Method of inhibiting the proliferation and migration of helicobacter pylori
  • Method of inhibiting the proliferation and migration of helicobacter pylori
  • Method of inhibiting the proliferation and migration of helicobacter pylori

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Table 5 shows the growth inhibitory effects of the test water for various Helicobacter pylori (Helicobacter pylori) strains.

[0076] table 5

[0077] Proliferation inhibitory effect on various Helicobacter pylori strains

[0078] No.

Bacteria name

A

B

C

D

E

F

G

1

KMT27

2

KMT31

3

KMT40

4

KMT44

5

KMT45

6

KMT46

7

KMT47

8

KMT50

9

NY1

10

NY8

11

NY11

12

NY31

13

...

Embodiment 2

[0083] Table 6 shows the motility inhibitory effect on various Helicobacter pylori strains cultured on agar medium using high mineral water obtained from deep ocean water.

[0084] Table 6

[0085] Proliferation inhibitory effect on various Helicobacter pylori strains

[0086] No.

Bacteria name

A

B

C

D

E

F

G

1

KMT27

2

KMT31

3

KMT40

4

KMT44

5

KMT45

6

KMT46

7

KMT47

8

KMT50

9

NY1

10

NY8

11

NY11

12

NY31

13

26695

14

HPK5

...

Embodiment 3

[0090] Using high-mineral water with a total mineral concentration of 400mg / kg as raw material, the total mineral concentration was changed to 20-11,800mg / kg according to the ion ratio shown in Table 7, and the effect on Helicobacter pylori (Helicobacter pylori) strains was investigated. growth inhibitory effect.

[0091] Table 7

[0092] Ion ratio of various mineral water (%)

[0093]

[0094] In consideration of operational unevenness in the test, when the CFU of the test water showed a value smaller than 80% compared with the control, it was determined that there was an effect. The test was carried out 3 times, and when the effect was observed more than 2 times, it was judged that the growth inhibitory effect was present (◯ mark).

[0095] However, the strains used were the Helicobacter pylori strains shown in 1-16.

[0096] The concentration of total minerals was increased sequentially from 20 to 11,800 mg / kg for discussion, and the results are shown in Tables 8 to 1...

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Abstract

It is known that Helicobacter pylori infects human stomach as a host inherent to it and fixes therein to thereby participate upper digestive tract diseases. It is intended to provide an economical method of inhibiting the proliferation and migration of Helicobacter pylori without any fear of the appearance of a drug-tolerant strain caused by a drug having been commonly employed for removing bacteria or side effects, which comprises selecting a mineral-rich water, which is capable of inhibiting the proliferation and migration of Helicobacter pylori that has infected human stomach as a host inherent to it and fixed therein from among mineral-rich waters obtained from deep marine water and taking the same, and a food and a drink with the use of the mineral-rich water.

Description

technical field [0001] The present invention relates to a method for inhibiting the proliferation and movement of Helicobacter pylori strains that are the main cause of gastric and duodenal ulcers, gastric cancer, and the like. [0002] More specifically, the present invention relates to a method for inhibiting the proliferation and movement of Helicobacter pylori strains inherent in a host without emergence of resistant bacteria and without side effects. [0003] In addition, the method of inhibiting proliferation and movement in the present invention refers to any method including inhibiting the proliferation of Helicobacter pylori strains and inhibiting the active movement of Helicobacter pylori strains. Background technique [0004] Deep ocean water has been drawn from Cape Muroto, Kochi Prefecture for the first time in 1989 through land-based deep water intake facilities, and water has been drawn from all over Japan, mainly in Toyama and Okinawa prefectures. Deep ocean...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/02A61K33/06A61K33/00A23L1/304A61P31/04A23L33/16A61K35/08
CPCA61K33/00A61K33/06A61K35/02A23L1/304A23L33/16A61P31/04A61K2300/00A61K9/08
Inventor 竹内启晃池上良成安川岳志中川光司
Owner AKO KASEI CO LTD
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