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Preparation of bletilla striata polyose water gelatin of promoting wound healing and uses thereof

A technology of bletilla striata polysaccharide and hydrogel, which is applied in the field of biomedicine, can solve the problems of insignificant biological functions, achieve the effects of shortened healing time, no bacterial infection, and convenient use

Inactive Publication Date: 2008-08-27
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The polymer hydrocolloid is a dressing that absorbs highly exudate, and the amount of exudate absorbed can reach more than 12 times its own mass, and has good biocompatibility, but its biological function is not significant

Method used

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  • Preparation of bletilla striata polyose water gelatin of promoting wound healing and uses thereof
  • Preparation of bletilla striata polyose water gelatin of promoting wound healing and uses thereof
  • Preparation of bletilla striata polyose water gelatin of promoting wound healing and uses thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] 1. Preparation of hydrogel (1)

[0029] Dissolve 2g of pure Bletilla striata polysaccharide in deionized pure water, add 0.3g-1.0g of sodium periodate, stir evenly, react for 24 hours, obtain alhydized Bletilla striata polysaccharide after dialysis with deionized pure water, and store at 4°C.

[0030]According to the mass ratio of aldylated Bletilla striata polysaccharide and cross-linking agent hexamethylenediamine is 20:1 or 8:1 or 4:1 or 2:1 or 1:1 or 1:2, after mixing, heating and evaporating water solvent to obtain different The proportioned Bletilla striata-hexamethylenediamine hydrogel was sealed and stored in a refrigerator at 4°C. Bletilla striata-hexamethylenediamine hydrogels with different ratios were in the form of transparent sheets. Under the ratio of 20:1, 8:1, 4:1, 2:1, the hydrogel was brittle and fragile, and its mechanical strength was poor. Under the ratio of 1:1 and 1:2, the hydrogel has certain toughness and elasticity, and the mechanical streng...

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Abstract

The invention belongs to the biological medical technology field, and discloses a medical polysaccharides hydrogel used for surgical healing which consists of aldehydized bletilla striata, crosslinking agent and deionized pure water; the weight percentage of the polymer is 3 to 25 percent. The hydrogel is characterized in good anti-inflammatory action, good permeability, good moisture retention and the function of absorbing trauma secretion, improving obviously the speed of trauma healing in animal model, and having a wide application prospect as an ideal medical surgical healing medicine.

Description

1. Technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a polysaccharide hydrogel for medical surgical callus and a preparation method thereof. 2. Background technology [0002] The basic goal of treating skin wounds is to speed up the healing of wounds, prevent bacterial infection, reduce the pain caused by bleeding, inflammation, wound infection and even ulcers, prevent the negative impact of trauma on physiological functions, and make the wound as beautiful as possible after healing. Skin wound healing events are divided into coagulation phase, inflammation phase, cell proliferation phase, and tissue remodeling phase. It is a complex process involving many factors such as coagulation, inflammation, vascular remodeling, epithelial cell proliferation and migration, and tissue remodeling. The result of injury is also determined by the balance among these many factors [Mehrdad Kokabi, Mohammad Sirousazar, Zuhair Muha...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 张峻峰罗熠刁华佳夏苏华陈江宁
Owner NANJING UNIV
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