Method for synthesizing natural tocopherol ester catalyzed by lipase

A lipase and tocopherol technology, which is applied in the field of lipase-catalyzed synthesis of natural tocopherol esters, can solve the problems of many toxic by-products, large waste water, and difficulty in continuous production, and achieve the effects of low toxicity, long life and easy separation

Inactive Publication Date: 2008-08-13
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the acidity and alkalinity of the catalyst and the excess of the acid anhydride of the substrate, neutralization and washing are required, which will cause a large amount of waste water and cause environmental pollution problems
In addition, there are disadvantages such as complex process, difficult separation of products, many toxic by-products, and it is difficult to achieve continuous production in industry

Method used

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  • Method for synthesizing natural tocopherol ester catalyzed by lipase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Two kinds of substrates 0.43g (1mmol) natural α-tocopherol and 0.185ml (2mmol) ethylene acetate are joined in the sherwood oil of 0.5% water content in reaction medium 10ml, react with 0.02g free Candida lipase (10000U / g) as a catalyst. Under the condition of temperature of 40° C., the shaking table was oscillated (180 r / min), and the reaction conversion rate reached 50.00% after 72 hours of reaction. After the reaction was completed, stand at room temperature and filter to separate free lipase. The organic solvent is distilled off from the reaction solution under a vacuum degree of 0.05-0.08 MPa to obtain the product natural tocopheryl ester.

Embodiment 2

[0037] The operation steps are the same as in Example 1, except that the catalyst is changed from free Candida lipase to Penicillium lipase, and the conversion rate is 45.21%.

Embodiment 3

[0039] Two kinds of substrates 0.43g (1mmol) natural α-tocopherol and 0.185ml (2mmol) ethylene acetate are added in reaction medium 10ml water content and be 0.5% petroleum ether, the lipase immobilized with 0.2g textile cotton cloth is reacted (250U / g) is the catalyst. Under the condition of temperature 40° C., the shaking table was oscillated (180 r / min), and the reaction conversion rate reached 91.03% after 72 hours of reaction. The immobilized lipase is taken out, the reaction solution is filtered, and the organic solvent is evaporated under a vacuum of 0.05-0.08 MPa to obtain the product natural tocopheryl ester.

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Abstract

The invention discloses a method for catalyzing and synthesizing savageness tocofecol ester by lipase. savageness tocofecol and a unsaturated carboxylic ether in ratio range of 1:1-1:5 are added into reaction media organic solvent and lipase is used as energizing agent. The esterification rate of savageness tocofecol can be up to 9525023440n condition of 20-60 0.000000or 48-72 hours. The dosage of lipase is 0.5 times of the quantity of tocofecol and the carrier of lipase is textile fabric or colophony. Comparing with the present method in chemical catalyst, the invention has advantages such as gentle reaction condition, low energy consumption, simple product separation and less poison accessory substances.

Description

technical field [0001] The invention relates to a lipase-catalyzed method for synthesizing natural tocopheryl esters. technical background [0002] Vitamin E (Vitamin E) is a kind of vitamin related to reproductive function. The chemical structure is all chroman derivatives, and there are phenolic hydroxyl groups in the structure, so it is also called tocopherol. It is known that there are mainly eight isomers of α, β, γ, δ, ε, ζ1, ζ2, and η, among which α-tocopherol has the strongest activity. Tocopherol not only plays an important role in nutrition, but also has a very prominent function in the prevention of chronic diseases, which is unmatched by other vitamins. The physiological functions of tocopherol include anti-oxidation, improving the immune function of the body, anti-cancer or tumor-inhibiting effects, and anti-sterility functions. Therefore, it is widely used in medicine, food, cosmetics and other fields. [0003] Tocopherol is divided into two types: synthetic...

Claims

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Application Information

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IPC IPC(8): C12P17/06
Inventor 王芳龚学兵谭天伟邓利聂开立
Owner BEIJING UNIV OF CHEM TECH
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