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Application of Chinese medicine composition in preparing medicament for adjusting cardiac muscle cell potassium ion channel

A composition and technology of traditional Chinese medicine, applied in the application field of traditional Chinese medicine composition in the preparation of potassium ion channel regulating drugs in cardiomyocytes, which can solve the problems of limited application field and undisclosed potassium ion channel regulating effect

Active Publication Date: 2012-05-23
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent does not disclose the regulatory effect of the pharmaceutical composition on potassium ion channels, and the application field is limited to the treatment of premature ventricular contractions in coronary heart disease. The present invention has made further research on the basis of the patented technology again

Method used

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  • Application of Chinese medicine composition in preparing medicament for adjusting cardiac muscle cell potassium ion channel
  • Application of Chinese medicine composition in preparing medicament for adjusting cardiac muscle cell potassium ion channel
  • Application of Chinese medicine composition in preparing medicament for adjusting cardiac muscle cell potassium ion channel

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Experimental program
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Effect test

Embodiment 1

[0045] In order to facilitate the application of the potassium ion channel regulation effect of the Chinese medicine composition, the Chinese medicine composition is prepared as a capsule

[0046] prescription:

[0047] Ginseng 89g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 224g

[0048] Fried Suanzaoren 186g, Sangjisheng 186g, Radix Paeoniae Rubra 89g, Ground Beetle 75g

[0049] Gansong 89g Coptidis 45g Southern Schisandra 67g Keel 149g

[0050] Preparation:

[0051] a) In the above prescription, ginseng was extracted three times with 70% ethanol under reflux, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, crushed into fine powder, and set aside;

[0052] b) In the above prescription, Schisandra chinensis, Cornus officinalis, Salvia miltiorrhiza, Coptis chinensis, and Gansong are refluxed and extracted three times with 70% ethanol, the extracts ar...

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Abstract

The invention provides an application of a Chinese traditional medicine composition in regulation of potassium ion channel in myocardial cells. The Chinese traditional medicine composition inhibits an inward rectifier potassium current, a transient outward potassium current and delays an outward rectifier potassium current in a voltage dependent mode, which prolong the action potential duration (APD) to play a role of anti-arrhythmic effect through lowering the excitability of myocardial cells and inhibiting the repolarization process of the action potential (AP) of the myocardial cells.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine composition in the regulation of myocardial cell potassium ion channels and the application in the preparation of drugs for treating arrhythmia. Background technique [0002] Cardiovascular diseases, such as hypertension, coronary heart disease, and arrhythmia, have become major diseases that endanger human health, and their morbidity and mortality rates rank first in the world. Severe arrhythmias, such as tachyventricular tachycardia (VT), ventricular fibrillation (VF) and cardiac death (SCD), are important causes of cardiovascular death. [0003] The normal pumping function of the heart depends on the rhythmic contraction and relaxation of the myocardium, and the formation and conduction process of myocardial cell membrane excitation is the initiating factor that triggers the rhythmic contraction and relaxation of the heart. The formation and conduction of myocardial excitati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/08A61K9/10A61K9/14A61K9/20A61K9/48A61P9/06A61K35/64A61K35/02
Inventor 浦介麟李宁马克娟
Owner HEBEI YILING MEDICINE INST
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