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Medicine compounds used for cardiovascular disorders

A composition and cardiovascular technology, which is applied in cardiovascular system diseases, drug combination, drug delivery, etc., can solve problems such as difficulty in lowering systolic blood pressure, achieve definite antihypertensive effect, restore circadian rhythm of blood pressure fluctuations, and have good curative effect

Active Publication Date: 2008-07-30
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the current process of clinical hypertension drug treatment, the reduction of systolic blood pressure is one of the difficulties in the treatment of hypertension, especially for many elderly hypertensive patients, it is difficult to lower the systolic blood pressure

Method used

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  • Medicine compounds used for cardiovascular disorders
  • Medicine compounds used for cardiovascular disorders
  • Medicine compounds used for cardiovascular disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Hypertension compound tablet

[0018] Isosorbide Mononitrate 18g

[0019] Valsartan 108g

[0020] Spironolactone 0.1g

[0021] Microcrystalline Cellulose 100g

[0022] 8% hydroxypropyl methylcellulose solution appropriate amount

[0023] Low-substituted hydroxypropyl cellulose 50g

[0024] Magnesium Stearate 2g

[0025] Preparation process: It is prepared according to the conventional process of tablets.

Embodiment 2

[0026] Embodiment 2 hypertension compound tablet

[0027] Isosorbide Mononitrate 0.5g

[0028] Valsartan 3g

[0029] Spironolactone 6g

[0030] Microcrystalline Cellulose 100g

[0031] 8% hydroxypropyl methylcellulose solution appropriate amount

[0032] Low-substituted hydroxypropyl cellulose 50g

[0033] Magnesium Stearate 2g

[0034] Preparation process: It is prepared according to the conventional process of tablets.

Embodiment 3

[0035] Embodiment 3 hypertension compound capsule

[0036] Isosorbide Mononitrate 25g

[0037] Irbesartan 600g

[0038] Spironolactone 0.3g

[0039] Lactose 20g

[0040] Microcrystalline Cellulose 30g

[0041] Sodium carboxymethyl starch 5g

[0042] 10% starch slurry appropriate amount

[0043] Preparation process: Pass isosorbide mononitrate, irbesartan, spironolactone, lactose, microcrystalline cellulose and sodium carboxymethyl starch in the prescription through a 100-mesh sieve, mix well, add 10% starch slurry to granulate in an appropriate amount, Dry below 60°C, sieve through a 18-mesh sieve, and fill the capsules.

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PUM

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Abstract

The invention relates to a drug composition for curing cardiovascular system diseases and the key point is that the invention which combines sartans, aldosterone receptor antagonist and isosorbide mononitrate according to certain proportions becomes a novel drug which cures the cardiovascular system diseases such as hypertension and heart failures and achieves ideal treatment effects comprehensively considered. The invention has the advantages that 1. The invention has a good effect in anti-myocardial fibrosis anti-ventricular hypertrophy as well as effective antihypertensive. 2. The invention is good in treating simple systolic hypertension of the elderly, exact in hypertensive effect, stable in operation and has no drug resistance. 3. The invention has active influences on the prognosis of patients of hypertension and the related complications, which is also the most meaningful clinical treatment problems which are solved by the invention.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating hypertension. Background technique [0002] Cardiovascular disease is a kind of disease that seriously endangers human health. With the advancement of society and the improvement of human living standards, the incidence of such diseases has increased year by year, becoming the number one killer threatening human health. Hypertension, as the most common cardiovascular disease, has an increasing incidence and a trend of younger age. Various complications caused by hypertension, such as myocardial hypertrophy, myocardial fibrosis, heart failure, myocardial ischemia and arrhythmia, are important reasons for the decline in the quality of life and long-term survival of hypertensive patients. This has aroused the great attention of medical workers. After continuous and in-depth research on the pathogenesis of hypertension, great achievements have been made in the etiology, pathology, physiol...

Claims

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Application Information

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IPC IPC(8): A61K31/4184A61K31/41A61K45/06A61K9/16A61K9/20A61K9/22A61K9/48A61P9/12A61P9/00A61K31/34
Inventor 赵志全姚景春
Owner LUNAN PHARMA GROUP CORPORATION
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