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Chinese traditional medicine compounds for treating Alzheimer's disease and preparing method thereof

A technology of Alzheimer's disease and composition, applied in the field of traditional Chinese medicine, can solve the problems of ineffective inhibition, etc., achieve the effect of alleviating delayed neuronal cell death and cortical atrophy, significant curative effect, and relieving occurrence and development

Inactive Publication Date: 2012-06-06
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the existing Chinese and Western medicines cannot effectively inhibit the above-mentioned core pathological process of excessive production of Aβ40 or Aβ42.

Method used

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  • Chinese traditional medicine compounds for treating Alzheimer's disease and preparing method thereof
  • Chinese traditional medicine compounds for treating Alzheimer's disease and preparing method thereof
  • Chinese traditional medicine compounds for treating Alzheimer's disease and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take each raw material by the following weight: gardenia 150g, Panax notoginseng total saponins 4g;

[0035]Grind Gardenia Fructus into coarse powder, percolate with 50% ethanol, collect percolate, recycle ethanol, concentrate to obtain clear paste 1; dilute clear paste 1 with 3 times the weight of water, stir well, refrigerate, filter, Concentrate the filtrate under reduced pressure to obtain clear paste 2; put the clear paste 2 on an activated carbon column, first elute with distilled water until the eluent is colorless, then elute with 8 times the weight of 60% ethanol, collect the eluent, and recover under reduced pressure Ethanol is concentrated and dried to obtain the semi-finished product of Gardenia Fructus; after obtaining the semi-finished product of Gardenia Fructus, it is dissolved with an appropriate amount of water for injection, and filtered; another notoginseng total saponins (purchased from Yunnan Yuxi Wanfang Natural Medicine Co., Ltd., trade name: Pan...

Embodiment 2

[0037] Take each raw material by the following weight: Gardenia 200g, Panax notoginseng total saponins 6g;

[0038] Grind the Gardenia Fructus into coarse powder, percolate with 90% ethanol, collect the percolation liquid, recycle the ethanol, concentrate to obtain the clear paste 1; dilute the clear paste 1 with 5 times the weight of water, stir well, refrigerate, filter, Concentrate the filtrate under reduced pressure to obtain clear paste 2; put the clear paste 2 on an activated carbon column, first elute with distilled water until the eluent is colorless, then elute with 12 times the weight of 80% ethanol, collect the eluent, and recover under reduced pressure Ethanol is concentrated and dried to obtain the semi-finished product of Gardenia Fructus; after obtaining the semi-finished product of Gardenia Fructus, it is dissolved with an appropriate amount of water for injection, and filtered; another notoginseng total saponins (purchased from Yunnan Yuxi Wanfang Natural Medic...

Embodiment 3

[0040] Take each raw material by the following weight: gardenia 180g, Panax notoginseng total saponins 5g;

[0041] Grind the Gardenia Fructus into coarse powder, percolate with 70% ethanol, collect the percolation liquid, recycle the ethanol, concentrate to a relative density of 1.10 (measured at 60°C), and obtain the clear cream 1; add 4 times the weight of water to the clear cream 1 Dilute, stir well, refrigerate at 0-4°C for 48 hours, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10 (measured at 60°C) to obtain clear paste 2; put clear paste 2 on an activated carbon column, and first use distilled water Elute until the eluent is colorless, then elute with 10 times the weight of 70% ethanol, collect the eluent, recover the ethanol under reduced pressure and concentrate, dry to obtain the semi-finished product of Gardenia jasmine; Dissolve in water for injection, filter; take another Panax notoginseng saponins (purchased from Yunnan Y...

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Abstract

The invention discloses a traditional Chinese medicine composition used for curing alzheimer disease and a preparation method thereof. The traditional Chinese medicine composition is made from the following crude medicines by weight portion: 150-200 portions of gardenia and 4-6 portions of panax notoginseng saponins. The traditional Chinese medicine composition of the invention can effectively inhibit the overproduction of A beta 40 and A beta 42, interdict the sedimentation of amyloid protein, keep stable adjustment of calcium ions and depress oxidative damage and non-specific inflammatory reaction caused by amyloid plaques as well secondary lesion on neurons resulted from metabolic toxins, thus removing the occurrence and development of lesions, relieving delayed neuronal death and cortical atrophy and having obvious treatment effect on alzheimer disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating Alzheimer's disease and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] At present, in the clinical treatment of Alzheimer's disease (AD), traditional Chinese medicine is mainly aimed at the loss of kidney essence and the lack of nourishment of the brain. Memory, improve intelligence level, prevent the process of brain atrophy, or use spleen-replenishing, Qi-nourishing, blood-nourishing and tranquilizing medicines for heart and spleen deficiency, such as astragalus, Codonopsis ginseng, ginseng and polygala, etc., which have the effect of improving intelligence and memory. However, clinical efficacy has not been significantly improved because such treatments have little effect on the cascade of factors leading to amyloid deposition. Feasible West...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61P25/28A61K31/704
Inventor 李澎涛申勇华茜
Owner BEIJING UNIV OF CHINESE MEDICINE
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