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Novel medicament for treating systematic lupus erythematosus

A lupus erythematosus, systemic technology, applied in the field of medicine, can solve the problems of large side effects and inability to use for a long time, and achieve the effect of small side effects, low cost, and strong anti-systemic lupus erythematosus effect

Inactive Publication Date: 2008-06-11
邱日辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have a certain effect on the treatment of systemic lupus erythematosus, but the side effects are very large and cannot be used for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Accurately weigh 5 grams of total terpenes of Tripterygium wilfordii, 3.5 grams of hematoxylin, 1.5 grams of borneol and 20 grams of polyethylene glycol 2000, place them in a heating container and heat while stirring until the temperature is 250°C A molten liquid or an emulsion or a suspension containing the dry powder of the drug and the matrix is ​​obtained.

[0020] Prepare dripping pills: adopt advanced dropping pill machine (TZDW-1 type dropping pill machine produced by Beijing Changzheng Tianmin High-tech Co., Ltd.), and adjust the temperature control system of the dropping pill machine, so that the dripper temperature of the dropping pill machine is heated and maintained At (50°C to 90°C), the temperature of the condensing agent is cooled and maintained at (4°C to -5°C). When the temperature of the condensing agent in the dripper of the dripping machine and the coagulation column is stable at the above required temperature state, the melt or emulsion o...

Embodiment 2

[0023] Example 2: Accurately weigh 10 grams of total terpenes of Tripterygium wilfordii, 7 grams of hematoxylin, 3 grams of borneol, and 40 grams of polyethylene glycol 4000, place them in a heating container, heat while stirring, and when the temperature rises to 250 ° C , to obtain a melt or emulsion or suspension containing the dry powder of the drug and the matrix.

[0024] Prepare dripping pills: adopt advanced dropping pill machine (TZDW-1 type dropping pill machine produced by Beijing Changzheng Tianmin High-tech Co., Ltd.), and adjust the temperature control system of the dropping pill machine, so that the dripper temperature of the dropping pill machine is heated and maintained At (50°C to 90°C), the temperature of the condensing agent is cooled and maintained at (4°C to -5°C). When the temperature of the condensing agent in the dripper of the dripping machine and the coagulation column is stable at the above required temperature state, the melt or emulsion or suspens...

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Abstract

The invention relates to a new drug for curing systematic lupus erythematosus, which comprises a dropping pill and oral liquid. Three Chinese medicine ingredients of tripterygium wilfordii total terpene 5% to 25%, haematine 5% to 25%, and baras camphor 2% to 8% are mixed in parts to be added into 62% to 68% preparation findings, and the invention is prepared through a simple process. The new drug of the innvntion has a strong function of anti-systematic lupus erythematosus in a mouse systematic lupus erythematosus illness mould, thereby the invention which is used on human clinic has a stronger treatment and rejection capabilities, the three drugs mutually reflect to produce significant harmonization role, which confronts a side effect which is brought by total terpene of tripterygium wilfordii, and the invention is led to be a non-toxic and most promising medicament to resist systematic lupus erythematosus. The invention has the advantages of significant effect, little side effect, simple preparation process and low cost, which must become a first choice drug to resist systematic lupus erythematosus.

Description

Technical field: [0001] The invention belongs to the field of medicines, in particular to a new medicine for treating systemic lupus erythematosus. Background technique: [0002] Lupus erythematosus is a disease of collagen tissue, that is, the human body's own immune system. Lupus erythematosus is divided into two types, systemic lupus erythematosus and discoid lupus erythematosus, which mostly occurs in adolescent and childbearing women, especially young women. The peak incidence is between 15-40 years old, and the ratio of male to female is 1:5-9. It is also seen in children and the elderly, and the difference between male and female incidence is narrowed in children and the elderly, and the ratio of male to female is about 1:2. In addition to heredity, infection, drugs, and environmental factors, the cause of the disease is also related to the endocrine system of the human body, especially female hormones, so it is more common in women. Discoid lupus erythematosus main...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K9/10A61K9/20A61K47/34A61P17/00A61P37/02A61K31/045A61K47/10
Inventor 张南
Owner 邱日辉
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