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Injection novel medicine for treating systematic lupus erythematosus

A lupus erythematosus and injection technology, which is applied in the field of medicine, can solve problems such as large side effects and cannot be used for a long time, and achieve the effect of strong anti-systemic lupus erythematosus effect.

Inactive Publication Date: 2009-04-08
张南 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have a certain effect on the treatment of systemic lupus erythematosus, but the side effects are very large and cannot be used for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 1 mg of arsenic trioxide in normal saline first, then add 40 mg of cinobufacin, stir to dissolve; finally add 40 mg of matrine and 1 mg of borneol, stir evenly to make the color into a light yellow liquid and sterilize it. finished product.

[0021] In the injection of this embodiment, every milliliter contains 1 milligram of arsenic trioxide, 40 milligrams of matrine, 40 milligrams of cinobufacin (containing serotonin at a concentration of 18 micrograms / ml or containing bufocin at a concentration of 25 micrograms / ml) and 1 mg borneol.

Embodiment 2

[0023] Dissolve 5 mg of arsenic trioxide in normal saline first, then add 50 mg of cinobufacin, stir to dissolve; finally add 50 mg of matrine and 5 mg of borneol, stir evenly to make the color into a light yellow liquid and sterilize it. finished product.

[0024] The injection in this example contains 5 mg of arsenic trioxide, 50 mg of matrine, 50 mg of cinobufacin and 5 mg of borneol per milliliter.

[0025] In order to further illustrate the outstanding effect of the injection of the present invention, the prepared single injection is compared with the injection of the present invention to prepare a single arsenic trioxide injection: dissolve arsenic trioxide (white color) with physiological saline, and each milliliter of arsenic trioxide injection contains 1 mg Arsenic trioxide.

[0026] Preparation of matrine oral liquid: dissolve matrine with normal saline, and each milliliter of matrine injection contains 1 mg of matrine.

[0027] Preparation of cinobufacin oral solu...

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PUM

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Abstract

The invention belongs to the medicine technical field, which particularly relates to a novel injection drug for treating systemic lupus erythematosus. In the invention, four drugs of arsenic trioxide, matrine, Chinese toad bufotoxin and borneol are mixed according to certain ratio to prepare a novel injection preparation for treating the systemic lupus erythematosus; when the injection preparation is used for tested mice with the systemic lupus erythematosus, the injection preparation has good function of resisting the systemic lupus erythematosus, the obvious synergic action is generated among the four drugs; and because the injection drug can resist side effects caused by the single arsenic trioxide injection liquid, the injection drug is the most promising non-toxic drug for resisting the systemic lupus erythematosus; as the novel injection drug is developed and put into use, the novel injection drug will become a first-choice drug for resisting the systemic lupus erythematosus.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, in particular to a new drug for treating systemic lupus erythematosus injection. Background technique: [0002] Lupus erythematosus is a disease of collagen tissue, that is, the human body's own immune system. "Lupus erythematosus, divided into two types of lesions, systemic lupus erythematosus and discoid lupus erythematosus, mostly occurs in adolescent and childbearing women, especially young women. The peak incidence is between 15 and 40 years old, and the ratio of male to female is 1:5- 9. It is also seen in children and the elderly, and the difference between male and female incidence is narrowed in children and the elderly, and the ratio of male to female is about 1:2. In addition to genetic, infection, drug, and environmental factors, the pathogenesis is also related to the endocrine of the human body , especially related to female estrogen, so it mostly occurs in women. Discoid lupus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61P37/02A61P29/00A61K31/4375A61K33/36A61K35/65
Inventor 张南李晓
Owner 张南
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