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Hippophae rhamnoides seed oil fatty milk injection and technique of preparing the same

A technology of seabuckthorn seed oil and injection, which is applied in the direction of emulsion delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as improper ratio of omega-6 and omega-3, and achieve Increase stability, reduce process flow, improve the effect of proportional imbalance

Inactive Publication Date: 2008-06-11
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention provides a seabuckthorn seed oil fat emulsion injection in order to solve the problem of improper ratio of omega-6 and omega-3 in the existing fat emulsion for injection. Fat emulsion for injection, good stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] a Stir and disperse 2.5g lecithin, 2.5g glycerin, 0.03g disodium edetate, and 60-90ml water for injection at 70-75°C to make the water phase; Preheat at ℃ (heating under the protection of N2) as the oil phase; c. Transfer the water phase into the tissue masher, add the oil phase to the dispersion, stir evenly at 5000-20000 rpm, repeat three times, Three minutes each time; d Take the above colostrum and add water for injection preheated to 70-75°C to make the full amount, adjust the pH of the colostrum to 9.0-9.5 with 0.1% NaOH, transfer it to a high-pressure homogenizer, and homogenize at 80MPa for 5- 10 times; e Pot the above emulsion into a 100ml infusion bottle, fill with nitrogen, sterilize in a rotating water bath at 119-123°C for 15-25min, cool down, and store in the dark at 6-20°C.

Embodiment 2

[0056] a Mix lecithin 2.0g, glycerin 2.5g, poloxamer F-68 0.20g, sodium oleate 0.1g, edetate disodium 0.03g, 60-90ml water for injection at 70-75℃ and stir to disperse evenly , as the water phase; b, preheat 10 g of seabuckthorn seed oil for injection at 70-75 ° C (heating under N2 protection), as the oil phase; c, transfer the water phase into a tissue grinder, and in this dispersion, Add the oil phase, stir evenly at 5000-20000 rpm, repeat three times, each time for three minutes; d take the above colostrum and add water for injection preheated to 70-75 ℃ to make the full amount, adjust the pH of the colostrum to 7.5 with 0.1% HCL -8.0, transfer to a high-pressure homogenizer, 80MPa pressure homogenization 5-10 times; e fill the above emulsion into a 100ml infusion bottle, fill with nitrogen, sterilize in a rotating water bath at 119-123°C for 15-25min to cool down, Store in the dark at 6-20°C.

Embodiment 3

[0058] a. Stir and disperse 1.8g soy lecithin, 2.5g glycerin, 0.02g disodium edetate, 0.1g anhydrous sodium sulfite, and 60-90ml water for injection at 70-75°C, as the water phase; b. Seabuckthorn seeds for injection 10g of oil is preheated at 70-75°C (heating under the protection of N2) as the oil phase; c. Transfer the water phase into the tissue masher, and add the oil phase to the dispersion liquid at 5000-20000 revolutions per minute Stir evenly, repeat three times, each time for three minutes; d take the above-mentioned colostrum and add water for injection preheated to 70-75°C to make the full amount, adjust the pH of the colostrum to 8.0-8.5 with NaOH solution, transfer it to a high-pressure homogenizer, 60 MPa pressure homogenization 5-10 times; e Pot the above emulsion into a 100ml infusion bottle, fill with nitrogen, sterilize in a rotating water bath at 119-123°C for 15-25min, cool down, and store in the dark at 6-20°C.

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Abstract

The invention discloses a medicament injection, which particularly relates to an injection which contains sea-buckthorn seed oil fat emulsion and a process for preparation. The sea-buckthorn seed oil fat emulsion of the invention is prepared according to the following components and proposition, 5 to 30g sea-buckthorn seed oil for injecting in each 100ml injection, 0.5 to 7.5g emulsifier, 1.5 to 3.6g isotonic regulator, 0.001 to 0.2g anti-oxidant, hydrochloric acid solution or sodium hydrate solution whose PH value is adjusted from 6.5 to 9.5, and the other are water for injecting. The proportions of the sea-buckthorn seed oil fat emulsion injection w-6 and w-3 are proper, and the stability is good, and the invention can not only provide heat energy for human bodies to replenish essential fatty acid for human bodies, but also the invention has the functions of improving body immunity, prompting tissue repair, anti-inflammatory anti-radiation and anti-mutation, and inhibiting cancer cell to diffuse. The invention particularly has a promoting effect to physical rapid restoration of postoperative patients, patients with large areas of burn, and cancer patients who have radiotheraphy and chemotherapy.

Description

technical field [0001] The invention relates to a drug injection, in particular to a fat emulsion injection containing seabuckthorn seed oil and a preparation method thereof. Background technique [0002] Fat is a drug with high calorific value and energy. When the human body encounters a disease and the energy supply is insufficient, it will use its own stored fat to maintain the body's metabolic function. When the human body cannot take fat energy orally due to disease for a long time, it is necessary to make fat substances into chylomicrons smaller than 0.5um and inject them into the human body through intravenous injection to meet the energy needs of the human body. Fat emulsions belong to this type of preparation, and its main components are fatty acids and triglycerides. There are many kinds of fatty acids in them. According to the length of the carbon chain in the molecular structure of fatty acids, they can be divided into short-chain fatty acids 2C-4C and medium-cha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/107A61K47/24A61K47/34A61P29/00A61P37/02A61P39/06A61P35/00A61K47/10A61K47/26
Inventor 唐星杨明明
Owner SHENYANG PHARMA UNIVERSITY
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