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Method for preparing polysaccharide selenate

A technology for selenate and polysaccharide, which is applied in the field of preparation and synthesis of polysaccharide selenate, can solve the problems of increased production cost of polysaccharide selenate, high consumption, water pollution, etc., and achieves easy separation, improved reaction efficiency, and easy to scale up production. Effect

Inactive Publication Date: 2008-06-04
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage of this polysaccharide selenate preparation method is exactly that the reaction product will be purified by membrane dialysis after the reaction is completed, and a large amount of water will be consumed in the purification process, and some organic matter such as pyridine, etc., after entering the circulating water It is difficult to be separated and removed, and it will cause serious pollution to water resources when it is discharged with the water body; selenium oxychloride is a high-value product, and a large amount of use will increase the production cost of polysaccharide selenate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Add 3 grams of anhydrous astragalus polysaccharide in the reaction vessel, add 56.7 grams of dioxane and 1.2 grams of pyridine to close the system, and when the temperature in the reaction vessel is 40 ° C, add dropwise 0.24 grams of selenium oxychloride and 5.2 grams of dioxane of the mixed solution. Control the rate of addition so that the temperature in the reaction vessel does not exceed 41°C. After the solution is added dropwise, react at 35°C for 5 hours, raise the temperature so that the temperature in the reaction vessel reaches 75°C and react for 20 minutes, stop the reaction, and cool to 25°C.

[0023] The crude product was suction-filtered under reduced pressure, and the crude product was washed with 3 ml of dioxane to recover dioxane. The crude astragalus polysaccharide selenate was washed with 10ml of ethanol and 10ml of acetone respectively, the ethanol and acetone were recovered, the collected solid was heated to 40°C and dried to obtain a brown-red powde...

Embodiment 2

[0025] Select 2.5 grams of anhydrous dextran as the anhydrous polysaccharide, and the others are the same as in Example 1. The selenium content of the obtained product is determined, and the selenium content of dextran selenate is 2153.2 μg / g.

Embodiment 3

[0027] Reaction is the same as in Example 1, the anhydrous polysaccharide is anhydrous astragalus polysaccharide, and the reaction medium is 45 grams of toluene, and the obtained product carries out the mensuration of selenium content, and the selenium content of astragalus polysaccharide selenate is: 2250 micrograms / gram.

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Abstract

The invention relates to a preparation synthetic method of polysaccharide selenic acid ester of organic selenium, in particular to a selenic acid esterification of polysaccharide in the medium of dioxane or toluene. A heterogeneous reaction is adopted in the preparation and the amount of the selenium oxychloride used is small, while the efficiency of polysaccharide selenizing reaction is greatly improved. The pure selenizing product is obtained by filtering and washing after the reaction. The production is easy to be expanded due to the heterogeneous suspended selenic acid esterification. Polysaccharide selenic acid ester is easy to be separated, and reaction medium and washing solvent can be recycled, so no environment pollution is caused.

Description

technical field [0001] The invention relates to a method for preparing and synthesizing polysaccharide selenate aimed at organic selenium. technical background [0002] Selenium is one of the 14 essential trace elements for the human body. It has various active functions such as anti-cancer, heart protection, liver necrosis, myopia and cataract prevention, detoxification, immunity improvement, anti-aging and enhancement of reproductive function. It is known as " The Kindling of Life", "The Patron Saint of the Heart" and "The King of Anti-Cancer". [0003] Studies have shown that the daily intake of selenium for adults is about 40-100 micrograms. The recommended selenium intake in my country is 50 micrograms per day for adults, 20-50 micrograms per day for children and adolescents, and 15 micrograms per day for infants. The human body's requirement for selenium is also different at different stages, and the selenium level of the body decreases with age. Therefore, the elderl...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715
Inventor 郭勇徐健梁卿邵士俊
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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