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Method for preparing carthamin yellow carthamus B and application thereof

A technology of safflower yellow pigment and safflower, which is applied to medical preparations, pharmaceutical formulations, plant raw materials and other directions containing active ingredients, can solve the problems of large dead adsorption, few reusable times of polyamide, and difficult elution. , to achieve the effect of simple processing of fillers, high reusability and increased yield

Active Publication Date: 2008-06-04
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the existence of some small molecule soluble amide impurities in polyamide, there is no unified detection item for its residues at present, and polyamide has strong adsorption to polyphenolic hydroxyl compounds, with a large amount of dead adsorption, which is difficult to wash off, and the repeatability of polyamide less use
However, safflower yellow pigment B contains multiple phenolic hydroxyl groups, and there are also adjacent phenolic hydroxyl groups, which are firmly adsorbed by polyamide, and the relative loss is relatively large when separated by polyamide.

Method used

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  • Method for preparing carthamin yellow carthamus B and application thereof
  • Method for preparing carthamin yellow carthamus B and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038]Weigh 20kg of dried safflower, soak it with 200L deionized water for 24 hours, then transfer it to the percolation barrel for percolation extraction, the flow rate is 0.06BV / min, and the medicinal materials are continuously replenished with fresh deionized water until the percolation liquid There is basically no safflower red pigment B in the medium, the total water consumption is 520L, the percolation liquid is combined, concentrated under reduced pressure at 60°C to a relative density of about 1.10, and put on the treated HP-20 macroporous adsorption resin column, the resin consumption is 20L, First elute 5 column volumes with 10% ethanol, discard this part of the eluate, and use 50% ethanol to elute, until the remaining liquid is basically free of safflower yellow B, combine the 50% ethanol eluate, Concentrate under reduced pressure at 60°C to a relative density of 1.20, add 95% ethanol under stirring to make the alcohol content 81%, leave it in a cold place for 24 hou...

Embodiment 2

[0040] Weigh 20 kg of dried safflower, soak it with 60% ethanol for 24 hours, then transfer it to the percolation bucket, and carry out percolation extraction. The flow rate is 0.06BV / min. There is basically no safflower red pigment B in the liquid, a total of 520L is used with 60% alcohol, the percolation liquid is combined, concentrated under reduced pressure at 60°C to a relative density of about 1.10, and put on a treated AB-8 macroporous adsorption resin column , the amount of resin used is 20L, first elute with 5% ethanol for 5 column volumes, discard this part of the eluate, and use 30% ethanol to elute, until the effluent is basically free of safflower yellow B, merge 30% Ethanol eluate, concentrated under reduced pressure at 60°C to a relative density of 1.20, added 95% ethanol under stirring to make the alcohol content 75%, left it in a cold place for 24 hours, a yellow precipitate precipitated, filtered, took the yellow precipitate, added 4 times The precipitated de...

Embodiment 3

[0042] Weigh 20kg of dried safflower, soak it with 200L of 50% ethanol for 24 hours, then transfer it to the percolation barrel, and carry out percolation extraction. The flow rate is 0.06BV / min. There is basically no safflower red pigment B in the filtrate, a total of 520L of 50% ethanol is used, the percolation liquid is combined, concentrated under reduced pressure at 60°C to a relative density of about 1.10, and the treated D-101 macroporous adsorption Resin column, the amount of resin used is 20L, first elute with 15% ethanol for 5 column volumes, discard this part of the eluate, and use 40% ethanol to elute until the remaining liquid is basically free of safflower yellow B, combine 40% ethanol eluate, concentrate under reduced pressure at 60°C to a relative density of 1.20, add 95% ethanol under stirring to make the alcohol content 85%, leave it in a cold place for 24 hours, a yellow precipitate precipitates, filter, and take the yellow precipitate, Add 5 times the amoun...

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Abstract

The invention relates to a preparation method of safflower yellow B and the application thereof. The safflower is extracted after immersion and diacolation in polar solvent and is then treated with refinement and separation by a method of combining chromatographic column and alcohol precipitation so as to obtain the safflower yellow B of the invention. The preparation method for the safflower yellow B of the invention can improve the yield of the safflower yellow B and is applicable to commercial production. In addition, the safflower yellow B obtained after separation can be used for preventing and curing cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the field of extraction and preparation of active ingredients of natural medicines, and specifically relates to a process for separating hydroxysafflower yellow B from safflower, and also relates to the application of hydroxysafflower yellow B in the fields of pharmacy and cardiovascular and cerebrovascular. Background technique [0002] Safflower is the dried flower of Carthamus tinctorius L., a plant in the Compositae family. It is picked in summer when the flowers turn from yellow to red, and dried in the shade or in the sun. There are three main water-soluble yellow pigments in safflower, which are hydroxyl safflower yellow A, safflower yellow B, and safflower yellow C. At present, many studies—including extraction methods, pharmacology and clinical studies—are focused on hydroxysafflower yellow A, and there are fewer studies on the other two components. Chinese patent CN1785988A discloses a preparation method and applicat...

Claims

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Application Information

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IPC IPC(8): C07D309/10A61K31/352A61K36/286A61P9/10
Inventor 张树祥熊国裕
Owner BEIJING SUNHO PHARMA
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